Synthesis of a New Photolabile Tritiated Antamanide- Analogue

Chapters in this book

1. Frontmatter I
2. PREFACE VII
3. CONTENTS IX
4. PEPTIDE SYNTHESIS AND ANALYTICAL PROBLEMS OF SYNTHETIC PEPTIDES
5. Enzyme-Catalyzed Semisyntheses with Porcine Insulin 1
6. Preparation, Properties and Application of Photo- Reactive Insulins 11
7. Synthesis of A19-[3,5-Diiodo-Tyrosine] Porcine Insulin 17
8. Semisynthesis of Linear Proinsulin Analogues with Shortened C-Peptides 23
9. Synthesis of Unsymmetrical Cystine Peptides: Directed Disulfide Pairing with the Sulfenohydrazide Method 29
10. Synthesis of Mid Regional Parathyrin Segments 35
11. Application of Modern Methods in the Synthesis of Cyclic Analogues of Bradykinin 41
12. Total Synthesis of Neurotoxin II from Naja Naja Oxiana Cobra Venom 47
13. The Synthesis of the N-Terminal Amino Acids of the Peptide-Nucleoside Antibiotic Nikkomycin and their Use in Peptide Synthesis 55
14. Synthesis and Activity of Peptides Analogues to the Toxic Peptides Isolated from Amanita Virosa Mushrooms 63
15. Synthesis of a New Photolabile Tritiated Antamanide- Analogue 71
16. Synthesis and Properties of (NLe^56'60 ) 34-65 Bacteriorhodopsin Fragment 79
17. Synthetic Peptide Derivatives of Bacterial Lipoprotein and their Interaction with Lymphocyte Plasma Membranes 87
18. Syntheses of Defined Peptide Derivatives by Aminolysis of 3-[N -Benzyloxycarbonyl Peptidyloxy]-2-Hydroxy-NMethyl- Benzamides at Elevated Temperatures II. Synthesis of the Peptide Derivatives Z-Ala-X-Gly-N(Et)₂, X=Phe, Leu, Val, Ser (Bu^t), Glu (OBu^t) 97
19. Recently Developed Amino Protecting Groups 103
20. Syntheses and Reaction of Peptide Cyclols 115
21. Synthesis of Cyclic Tripeptides Containing CONH Groups 121
22. Conformational Preferences of Model Peptides and their Impact in Peptide Synthesis 127
23. Analytical Studies on Side Products in the Synthesis of Secretin 137
24. High Performance Liquid Chromatography of Protected Peptides 145
25. Field Desorption Mass Spectra and Fast Atom Bombardment Spectra of Partially Protected Peptides 155
26. STRUCTURAL FEATURES OF PEPTIDES AND PROTEINS
27. Isolation and Structural Analysis of a New Neuropeptide, the Head Activator 165
28. Biochemical, Biological and Immunological Characterization of Bovine Nerve Growth Factor 171
29. Embryonic Haemoglobins in Mammals Haemoglobin Components in Human and Pig Embryos; Primary Structures of the Human and Pig-Chains and their Phylogenetic Relationship to the a-Chains 179
30. The Complete Primary Structure of Elongation Factor G from E-coli 187
31. The Primary Structure of E.coli RNA Polymerase. Nucleotide Sequence of the rpoC Gene and Amino Acid Sequence of the ß'-Subunit 195
32. Determination of Amino Acid Sequences of Large Hydrophobic Peptides of Rhodopsin 203
33. Three-Dimensional Structure of Actinoxanthin at High Resolution 209
34. Primary and Secondary Structures of Peptides which Form Voltage-Dependent Pores in Lipid-Bilayers 215
35. Purification and Characterization of a Second Retinal Binding Protein in Halobacterium Halobium 227
36. Homo- and Heteronuclear Two-Dimensional NMR Spectroscopy of Cyclic Peptides 233
37. MISCELLANEOUS AND BIOLOGICAL ACTIVITY OF PEPTIDES AND PROTEINS
38. Bioorganic Chemistry of Rhodopsins 241
39. The Role of Tyrosine 26 and Tyrosine 64 in Bacteriorhodopsin Function 249
40. Structure-Function Studies on Gastrin Related Peptides 255
41. Analogues of Angiotensin with Vasodepressor Activity 261
42. Regulatory Influence of Peptide Hormones on Neural Cells in Culture 267
43. Enzyme Immunoassay of Human Urinary Kallikrein 273
44. The Alamethicin Pore is Formed by a Voltage-Gated Flip-Flop of α-Helix Dipoles 281
45. Conformations of the Transmembrane Channel Formed by Gramicidin A 291
46. Study of Veratridine Receptors Associated with Sodium Channels 301
47. The Role of Neurotoxins in Studying Sodium Channels 309
48. Structure and Mechanism of Action of Neurotoxins from the Venom of Latrodectus Spiders 319
49. Topography of the Acetylcholine Receptor - Neurotoxin Binding Sites Probed by Spectroscopy and Photolabeling 327
50. Peptides as Iron Ionophores (Siderophores) 333
51. Interaction of Proteinases and their Protein Inhibitors as Studied by the Spin-Label Technique 343
52. An Inhibitor of Elastase from Anemonia sulcata 349
53. Phosphorylated Membrane Proteins PP 105 and PP 135 as Markers of Metastasizing Cells? 357
54. The Acrosomal Membrane System and its Role in Mammalian Fertilization 363
55. Penicillin-Like Action of a Bactericidal Protein (Colicin M) of Escherichia coli 371
56. Structure, Function and Biosynthesis of the Sperm Proteinase Acrosin 377
57. Structure-Functional Studies of DNA-Dependent RNAPolymerase 387
58. Affinity Labeling of the Binding Site for Initiation Substrate in E. coli DNA-Dependent RNA Polymerase by Adenosine-5'-Tri-Metaphosphate 395
59. Localization of Mutations Resulting in Rifamicin- Resistancy of E. coli RNA Polymerase 403
60. Role of Cyclic AMP in the Regulation of Genome Expression of Eukaryots 413
61. Cloning and Expression of the Human Leucocyte Interferon Gene 421
62. LIST OF CONTRIBUTORS 427
63. AUTHOR INDEX 429
64. SUBJECT INDEX 463
65. Backmatter 498