9 Zurich, Switzerland, September 3–8, 1989

Book

9 Zurich, Switzerland, September 3–8, 1989

Edited by: Hans-Christoph Curtius , Sandro Ghisla and Nenad Blau

Part of the multi-volume work

Chemistry and Biology of Pteridines

Language: English

Published/Copyright: 1990

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Frontmatter Publicly Available Download PDF	I
Preface Nenad Blau, Sandro Ghisla and Hans-Christoph Curtius Publicly Available Download PDF	VII
Adrien Albert Wolfgang Pfleiderer Publicly Available Download PDF	XI
Alois Niederwieser Hans-Christoph Curtius Publicly Available Download PDF	XII
Tetsuo Shiota Hans-Christoph Curtius Publicly Available Download PDF	XIII
Contents Publicly Available Download PDF	XV
I CHEMISTRY OF PTERINS AND FOLATES
Recent progress in pteridine chemistry M. Bischler, L. Kiriasis, D. Mohr, Z. Kazimierczuk, M. Wiesenfeldt, K. Abou-Hadeed and W. Pfleiderer Requires Authentication Unlicensed Licensed Download PDF	3
Synthesis of pteridines for immunoassay of biopterin and neopterin isomers T. Sugimoto and S. Matsuura Requires Authentication Unlicensed Licensed Download PDF	17
Design of new mechanism-based substrates for dihydrofolate reductase J.E. Gready Requires Authentication Unlicensed Licensed Download PDF	23
New methods for the synthesis of quinazoline antifolates and poly-y-glutamyl metabolites of folates and antifolates M. G. Nair, Donna Edwards, Ann Abraham and Shu Wen Li Requires Authentication Unlicensed Licensed Download PDF	31
The decay of quinoid- and 7,8-dihydropterins S.W. Bailey, A.A. Turner, S.B. Dillard and J.E. Ayling Requires Authentication Unlicensed Licensed Download PDF	43
Synthesis of 6-acetyl-2,4-diamino-7,8-dihydro-9//-pyrimido-[4,5-b][l,4]- diazepine, an amino analog of 6-acetyldihydrohomopterin H.A. Khattab, E.M. Hughes and P.H. Boyle Requires Authentication Unlicensed Licensed Download PDF	49
Synthetic approaches to methanopterin W. Pfleiderer and G. Heizmann Requires Authentication Unlicensed Licensed Download PDF	55
Synthesis and properties of tetrahydropterins coupled to 1,4-dihydropyridines W. Pfleiderer and J. Rehse Requires Authentication Unlicensed Licensed Download PDF	59
A new synthesis of biopterin and some analogues from epoxyaldehydes S. Murata, S. Ogiwara and T. Sugimoto Requires Authentication Unlicensed Licensed Download PDF	63
Synthetic studies on the molybdenum cofactor Reinhard Dotzer, lhab S. Darwish, Partha S. Ray and Edward C. Taylor Requires Authentication Unlicensed Licensed Download PDF	67
A new regiospecific synthesis of anapterin and primapterin R. Bosshard and M. Viscontini Requires Authentication Unlicensed Licensed Download PDF	73
A novel and efficient synthesis of folylpolyglutamates V. F. Silks and R. B. Dunlap Requires Authentication Unlicensed Licensed Download PDF	77
Reaction of acidic anhydride and pyridine with folic acid and classical antifolates Indira G. Nair and M.G. Nair Requires Authentication Unlicensed Licensed Download PDF	81
Quinazoline antifolate thymidylate synthase inhibitors: Synthesis of analogues containing heterocyclic isosteres of the para-aminobenzoate unit Anthony J. Hayter and Peter R. Marsham Requires Authentication Unlicensed Licensed Download PDF	86
Synthesis of tetrahydro-8-deazabiopterin T. Hayano, W. T. Colwell and J. I. DeGraw Requires Authentication Unlicensed Licensed Download PDF	90
Synthesis and enzymic properties of new mechanism based substrates for dihydrofolate reductase of the 8-substituted pterin class. R.K. Haynes and M.J. Koen Requires Authentication Unlicensed Licensed Download PDF	94
Imidazolines as carbon-transfer vehicles: models of the tetrahydrofolate (and other) coenzymes Mark J. Smallridge, John R. Nichols and Raymond C. F. Jones Requires Authentication Unlicensed Licensed Download PDF	98
Asymmetric synthesis and absolute configuration of 5,10-dideaza- 5,6,7,8-tetrahydropteroic acid and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid Thomas M. Wilson and Charles J. Barnett Requires Authentication Unlicensed Licensed Download PDF	102
Synthesis and biological evaluation of a fluorescent analogue of folic acid J.H. Freisheim, M. Ratnam, S.A. Patii, J.B. Hynes and T.P. McAlinden Requires Authentication Unlicensed Licensed Download PDF	106
Metal complexes of tetrahydroneopterin J . Strähle and B. Fischer Requires Authentication Unlicensed Licensed Download PDF	110
Syntheses of lipophilic analogues of 2-desamino-2-CH3-NIO-propargyl- 5,8-dideazafolate targeted at the enzyme thymidylate synthase (TS). A.H. Calvert, T.R. Jones, B. O’Connor, A.L. Jackman and G.M.F. Bisset Requires Authentication Unlicensed Licensed Download PDF	114
Studies in models of folate cofactors: oxidation of 5-methyltetrahydropterin revisited. U.K. Pandit, T.B.R.A. Chen and E. Hilhorst Requires Authentication Unlicensed Licensed Download PDF	118
New strategy in the synthesis of neopterin phosphates F. Neuheiser and B. Zagalak Requires Authentication Unlicensed Licensed Download PDF	122
First regiospecific synthesis of 7-iso-D-neopterin and 7-iso-D-neopterin- 3 '-monophosphate F. Neuheiser, B. Zagalak and H.-J. Borschberg Requires Authentication Unlicensed Licensed Download PDF	126
II. ANALYSIS OF PTERINS AND FOLATES
Detection of pterins in biological material using mass spectrometry F. Raschdorf, R. Dahinden, W.J. Richter, H.-Ch Curtius and Th Küster Requires Authentication Unlicensed Licensed Download PDF	133
Mass spectrometric methods for the structural determination of pteridines and folic acid derivatives M. Przybylski Requires Authentication Unlicensed Licensed Download PDF	140
Structural characterization of underivatized pteridines by laser desorption fourier transform mass spectrometry R. L. Hettich and K. Bruce Jacobson Requires Authentication Unlicensed Licensed Download PDF	147
New immunoassays for determination of biopterin and neopterin in body fluids A. Hey and H. Rokos Requires Authentication Unlicensed Licensed Download PDF	151
A new immunoassay for neopterin and biopterin S. Matsuura, S. Ogiwara, T. Sugimoto, T. Nagatsu, K. Kiuchi, K. Fujita, I. Nagatsu and M. Sakai Requires Authentication Unlicensed Licensed Download PDF	155
Enzyme immunoassay for urinary neopterin T. Iino, M. Tsusue, H. Sawada, T. Sugimoto, S. Matsuura and T. Mazuda Requires Authentication Unlicensed Licensed Download PDF	159
A competitive enzyme linked ligand sorbent assay (ELLSA) for quantitation of erythrocyte folates S.I. Hansen and J. Holm Requires Authentication Unlicensed Licensed Download PDF	163
Preparation of a bovine serum albumin based chiral matrix for resolution of (6R,S)-N⁵-formyltetrahydrofolate. D.S. Duch and R.J. Mullin Requires Authentication Unlicensed Licensed Download PDF	167
Rp-HPLC methods for the isolation and chemical identification of pterins from monocytic blood cells B. Andondonskaja-Renz, H.-J. Zeitler and H.W.L. Ziegler-Heitbrock Requires Authentication Unlicensed Licensed Download PDF	171
Cyclodextrin based HPLC separation of 6-S and 6-R diastereomers of 5,10-dideaza and 5-deazatetrahydrofolates. J.D. Snoddy, L.S. Gossett, P.M. Harrington, L.M. Osborne, G.M. Wilson and C. Shih Requires Authentication Unlicensed Licensed Download PDF	177
Analysis of folate and antifolate metabolites by mass spectrometry Susan Weintraub, Ann Abraham and M.G. Nair Requires Authentication Unlicensed Licensed Download PDF	181
A critical assessment of methods for measuring folate in human serum and red blood cells. C. Barley, A. Pollock, R. J. Leeming, G. Vaughan and C. G. B. Hamon Requires Authentication Unlicensed Licensed Download PDF	188
HPLC analysis of intracellular folate compounds after enzymic conversion to the corresponding pteroates F.M. Huennekens, Y.D. Montejano and K.S. Vitols Requires Authentication Unlicensed Licensed Download PDF	192
III. BIOSYNTHESIS AND BIOCHEMISTRY OF PTERINS
The Gowland Hopkins Lecture: Biosynthesis of H₄biopterin and related compounds G. M. Brown Requires Authentication Unlicensed Licensed Download PDF	199
The structure of_q-Bh₂ - chemistry and biochemistry Wilfred L.F. Armarego Requires Authentication Unlicensed Licensed Download PDF	213
Pteridines in riboflavin biosynthesis R. Volk, K. Schott and A. Bacher Requires Authentication Unlicensed Licensed Download PDF	219
Pteridine mimicking antibodies R.G.H. Cotton and I.G. Jennings Requires Authentication Unlicensed Licensed Download PDF	231
6-Pyruvoyl-tetrahydropterin reductases H.-Ch. Curtius, W. Leimbacher, P. Steinerstauch, B. Wermuth and S. Ghisla Requires Authentication Unlicensed Licensed Download PDF	238
Analysis of 6-pyruvoyl tetrahydropterin synthase, a target gene product of su(s) suppressor in Drosophila J. H. Kim, Y. S. Park, J. J. Yim and K. Bruce Jacobson Requires Authentication Unlicensed Licensed Download PDF	243
Synthesis of fluorinated 8-ribityllumazines as "F NMR probes and potential inhibitors of the light riboflavin synthase of Bacillus subtilis Donald A. Patrick, Hemantkumar H. Patel, Mark Cushman, Karin Schott and Adelbert Bacher Requires Authentication Unlicensed Licensed Download PDF	249
Studies on the oxidation state and biosynthesis of molybdopterin D. Pitterle, M. M. Wuebbens, M. Chaudhury, S. Gardlik, M. E. Johnson, J. L. Johnson and K. V. Rajagopalan Requires Authentication Unlicensed Licensed Download PDF	255
Molybdenum cofactor genes in Drosophila M. Olsen-Rasmussen, L.M. Arcangeli, M. Shelton and V. Finnerty Requires Authentication Unlicensed Licensed Download PDF	262
DNA photolyase: role of pterin in DNA repair. M.S. Jorns Requires Authentication Unlicensed Licensed Download PDF	268
7-Substituted pterins, a new class of mammalian pteridines A. Matasovic, C. Adler, H.-Ch. Curtius and M. Akino Requires Authentication Unlicensed Licensed Download PDF	274
Methanopterin: A structural and functional folic acid analogon in the biochemistry of methanogenic bacteria. G.D. Vogels, C. van der Drift, S.W.M. Kengen, B.W. te Brömmelstroet and J.T. Keltjens Requires Authentication Unlicensed Licensed Download PDF	285
Biosynthesis of methanopterin R. H. White Requires Authentication Unlicensed Licensed Download PDF	294
Tetrahydrobiopterin is required for the oxidation of arginine to nitric oxide by macrophages. Michael A. Marietta and Mahmoud A. Tayeh Requires Authentication Unlicensed Licensed Download PDF	300
Biosynthesis of 7-hydroxybiopterin M. Nakagoshi and S. Takikawa Requires Authentication Unlicensed Licensed Download PDF	306
GTP cyclohydrolase I from Escherichia coli. Molecular cloning and crystallization A. Bacher, C. Schmid and G. Katzenmeier Requires Authentication Unlicensed Licensed Download PDF	312
Molecular characterization of the GTP cyclohydrolase I gene of Drosophila: analysis of cDNA clones J.R. McLean and J.M. O’Donnell Requires Authentication Unlicensed Licensed Download PDF	316
Inhibitors of bovine adrenal medullary sepiapterin reductase Eric C. Bigham, Mark P. Edelstein, David S. Duch and Gary K. Smith Requires Authentication Unlicensed Licensed Download PDF	320
Catalytic implication of the reductase and isomerase activity of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin T. Sueoka and S. Katoh Requires Authentication Unlicensed Licensed Download PDF	324
Purification and characterization of sepiapterin reductase from human liver U. Redweik, F. Neuheiser and B. Zagalak Requires Authentication Unlicensed Licensed Download PDF	328
Biosynthesis of methanopterin and deazaflavin in Methanobacterium thermoautotrophicum A. Bacher, B. Schwarzkopf, W. Eisenreich and B. Reuke Requires Authentication Unlicensed Licensed Download PDF	332
Studies on riboflavin synthases of Bacillus subtilis. Amino acid sequence of the a subunit A. Bacher, E. Mehl, F. Lottspeicht, K. Schott and J. Kellermannt Requires Authentication Unlicensed Licensed Download PDF	336
Structure of the lumazine synthase/riboflavin synthase complex of Bacillus subtilis: crystallization of hollow reconstitutß₆₀, capsids. A Bacher, A König, R Ladenstein and K Schott Requires Authentication Unlicensed Licensed Download PDF	340
Biosynthesis of 6,7-dimethyl-8-ribityllumazine. Purification and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase A. Bacher, A. Kohnle, A. König and R. Volk Requires Authentication Unlicensed Licensed Download PDF	344
High resolution electron microscopy on crystals of the icosahedral lumazine synthase/riboflavin synthase complex. L. Bachmann, W. Baumeister, R. Ladenstein, K. Schott, A. Bacher and S. Weinkauf Requires Authentication Unlicensed Licensed Download PDF	348
Differential synthesis of LDH A-like proteins and of phosphoproteins in response to the modified deazaguanine-derivative queuine H. Kersten and U. Mahr Requires Authentication Unlicensed Licensed Download PDF	352
Metabolic control in HeLa-cells mediated by the deazaguanine-derivative queuine H. Kersten and W. Langgut Requires Authentication Unlicensed Licensed Download PDF	356
On the biosynthesis of the deazaguanine-derivative queuine: structure of the tgt gene of E. coli H. Kersten, B. Frey and K. Reuter Requires Authentication Unlicensed Licensed Download PDF	360
Changes in the level of biopterin and of queuine-containing tRNA during erythroid differentiation of murine erythroleukemia cells Susan Andrejchyshyn, Sarah Marx, Lawrence Kleiman and Michael A. Parniak Requires Authentication Unlicensed Licensed Download PDF	364
Brain contents of biopterins and monoamines after intraperitoneal injections of SUN0588, active 6R-tetrahydrobiopterin, during ontogeny in rats T. Noguchi, T. Ishihara, M. Takehisa, M. Furuya, M. Kawai, Y. Tani and Y. Watanabe Requires Authentication Unlicensed Licensed Download PDF	368
The effect of 2,4-diamino-6-hydroxypyrimidine on tetrahydrobiopterin and serotonin in the gastrointestinal tract of mice. A. Ichivama, H. Hasegawa, T. Kobayashi, N. Honda and E. Kaneko Requires Authentication Unlicensed Licensed Download PDF	372
Differential metabolism of tetrahydrobiopterin in central and peripheral monoamine neurons maintained in culture Vicki Kemski, Kei Hirayama, Hiroyuki Hasegawa and Gregory Kapatos Requires Authentication Unlicensed Licensed Download PDF	376
IV. TETRAHYDROBIOPTERIN DEFICIENCY
Inborn errors in tetrahydrobiopterin metabolism Hans-Christoph Curtius and Nenad Blau Requires Authentication Unlicensed Licensed Download PDF	383
Molecular defects in dihydropteridine reductase deficiency R.G.H. Cotton Requires Authentication Unlicensed Licensed Download PDF	389
Screening and treatment of tetrahydrobiopterin deficiency A. Ponzone, G.B. Ferrerò, O. Guardamagna, S. Ferraris, N. Blau and H.-Ch. Curtius Requires Authentication Unlicensed Licensed Download PDF	393
Tetrahydrobiopterin deficient phenylketonuria detected by neonatal screening in Taiwan Pao-Chin Chiu, Tzu-Tzu Liu, Szu-Hui Chiang, Kwang-Jen Hsiao and Kuang-Tung Wuu Requires Authentication Unlicensed Licensed Download PDF	402
Prenatal diagnosis of 6-pyruvoyl tetrahydropterin synthase deficiency in East Asia. G. Isshiki, Y. Sawada, M. Fujioka, H. Shintaku, T. Oura, S. Yamaoka, T. T. Liu, K. J. Hsiao and R.G. Chen Requires Authentication Unlicensed Licensed Download PDF	408
Heterogeneity of tetrahydrobiopterin deficiency: combined phenylalaninetetrahydrobiopterin loading test G.B. Ferrerò, S. Ferraris, O. Guardamagna, A. Ponzone, L. Kierat, H.-Ch. Curtius, N. Blau and R.G.H. Cotton Requires Authentication Unlicensed Licensed Download PDF	414
Unusual case of atypical PKU: peripheral or central form of PPH4S deficiency N. Blau, W. Endres, R. Ponzone, S. Ferraris, G.B. Ferrerò and O. Guardamagna Requires Authentication Unlicensed Licensed Download PDF	418
Development of vision in BH₄, deficiency A. Fea, L. Chiadò Piat, G. Porro, F. Vitale Brovarone, A. Ponzone, G.B. Ferrerò and A. Soldi Requires Authentication Unlicensed Licensed Download PDF	422
Fetal guinea-pig model of tetrahydrobiopterin deficiency G. Isshiki, H. Shintaku, M. Fujioka, Y. Sawada and T. Oura Requires Authentication Unlicensed Licensed Download PDF	426
Unexpected favorable clinical results of therapy in late diagnosed DHPR deficiency C. Romano, A.R. Fantasia, M.C. Schiaffino, S. Lupino, L. Maritano, U. Caruso and R. Cerone Requires Authentication Unlicensed Licensed Download PDF	430
Systematic investigation for biopterin defects in hyperphenylalaninemic patients G. Zignego, L. Maritano, R. Cerone, U. Caruso, C. Romano and N. Blau Requires Authentication Unlicensed Licensed Download PDF	434
Neuroradiological improvement after one year of therapy in a case of DHPR deficiency E. Riva, L. Saleri, M. Brioschi, M. Giovannini, R. Valsasina and G. Biasucci Requires Authentication Unlicensed Licensed Download PDF	438
V. PTERINS VARIOUS
Lumazine protein and the bioluminescence of photobacterium John Lee Requires Authentication Unlicensed Licensed Download PDF	445
Binding of pteridine derivatives to lumazine apoprotein J. Lee, D. J. O’Kane, A. Bacher and A. Kohnle Requires Authentication Unlicensed Licensed Download PDF	457
Hormonal imbalance by pteridine treatment in diapausing Pieridae induces mutations in the progeny of treated Drosophila melanogaster C. L’Hélias Requires Authentication Unlicensed Licensed Download PDF	462
N-acetyltransferase activity in Pieris brassicae J.M. Launay, J. Callebert and C. L’Hélias Requires Authentication Unlicensed Licensed Download PDF	466
VI. BIOLOGY OF PTERINS
Pteridines and the immune response. J. Tratkiewicz and Ch. Huber Requires Authentication Unlicensed Licensed Download PDF	473
Neopterin elevation and interferon induction in viral diseases H. Gelderblom, W. Lange, G. Pauli, K. Rokos and H. Rokos Requires Authentication Unlicensed Licensed Download PDF	485
Tetrahydrobiopterin in human T cells: control of its biosynthesis by interferon-y and interleukin 2 - modulator function in interleukin 2 perception K. Schott, I. Ziegler, U. Schwulera, A. Bacher and C. Schmid Requires Authentication Unlicensed Licensed Download PDF	491
Effects of BH₄ on the synthesis of serotonin in brain slices and synaptosomes: implications for the use of BH₄ as a therapeutic agent D.M. Kuhn, P.Z. Anastasiadis, H.A. Wolf and R.A. Levine Requires Authentication Unlicensed Licensed Download PDF	497
Regulation of cellular proliferation by tetrahydrobiopterin K. Tanaka, S. Kaufman and S. Milstien Requires Authentication Unlicensed Licensed Download PDF	505
Characterisation of the mutation in dihydropteridine reductase deficiency R.G.H. Cotton, S. M. Forrest, H-H.M. Dahl and D.W. Howells Requires Authentication Unlicensed Licensed Download PDF	511
Urinary excretion of total pteridines in cancer Sunil Trehan and J.M. Noronha Requires Authentication Unlicensed Licensed Download PDF	515
Alterations of interferon-gamma-induced monocyte activation by immunomodulating compounds determined by neopterin production H. Gelderblom, G. Pauli, K. Rokos and H. Rokos Requires Authentication Unlicensed Licensed Download PDF	519
Levels of neopterin, biopterin, 5-hydroxyindoleacetic acid, and homovanillic acid in cerebrospinal fluid of sick neonates and infants Y. Sawada, G. Isshiki, R. Murata, H. Shintaku, M. Fujioka, T. Katoh and A. Nishimura Requires Authentication Unlicensed Licensed Download PDF	523
Urinary neopterin levels in healthy children R. Izquierdo, B. Cañas, L.M. Polo, A. Panero, J.M. Jimenez and A. Nogales Requires Authentication Unlicensed Licensed Download PDF	527
Urinary neopterin factor in viral and bacteriological children infections J.L. Merino, J. Garcia and A. Nogales Requires Authentication Unlicensed Licensed Download PDF	530
Urinary neopterin levels in liver transplant J. Garcia, J.L. Merino, A. Nogales, R. Izquierdo, B. Cañas and L.M. Polo Requires Authentication Unlicensed Licensed Download PDF	534
The effect of IL-2, neopterin and immunomodulators on neopterin release from macrophages and PBMC N. Gruener and M. Barak Requires Authentication Unlicensed Licensed Download PDF	538
Membrane transport of unconjugated pteridines. The model of human erythrocytes. J.M. Hayte, J.L. Dhondt, J.P. Farriaux and C. Noël Requires Authentication Unlicensed Licensed Download PDF	543
Encephalopathy and abnormal cerebrospinal fluid pteridine profile. Fact or artefact ? G. Forzy, J.M. Hayte and J.L. Dhondt Requires Authentication Unlicensed Licensed Download PDF	547
Informativity of pteridine measurements in the survey of organ transplantations J.M. Hayte, J.L. Dhondt, M.P. Walter and C. Noël Requires Authentication Unlicensed Licensed Download PDF	551
Effect of triamteren on urinary excretion of pterins in different rat strains H. Gerding, L. Hanneken, K. Krause and G. Cremer-Bartels Requires Authentication Unlicensed Licensed Download PDF	555
Pteridines and retinal degenerations in rats and humans K. Krause, H. Gerding, G. Cremer-Bartels and L. Hanneken Requires Authentication Unlicensed Licensed Download PDF	559
Pterins in bovine, rat, quail and human retina L. Hanneken, G. Cremer-Bartels, K. Krause and H. Gerding Requires Authentication Unlicensed Licensed Download PDF	563
Comparison of urinary biopterin in rats with various housing and enviromental conditions M. Merkenschlager, G. Schramm, M. Roller and M. Goldberg Requires Authentication Unlicensed Licensed Download PDF	567
Differences in the quantity and distribution of urinary pterins in various species of mammals M. Merkenschlager, M. Koller and M. Goldberg Requires Authentication Unlicensed Licensed Download PDF	571
Total biopterin levels in the ventricular CSF of Parkinson's disease and essential tremor Y. Mizuno, K. Tanabe, F. Yokochi, K. Nishi, T. Kondo, Y. Furukawa and H. Narabayashi Requires Authentication Unlicensed Licensed Download PDF	575
Urinary xanthopterin and derivatives as indicators of liver disease K. Ogasawara, T. Mazda, A. Fukuda, W. L. Gyure and M. Tsusué Requires Authentication Unlicensed Licensed Download PDF	579
Genetic control of dihydropterin oxidase activity in Drosophila melanogaster J. Ferré, F.J. Silva, B. Escriche and E. Ordoño Requires Authentication Unlicensed Licensed Download PDF	583
A controlled system for supplementation experiments in Drosophila melanogaster F.J. Silva and B. Escriche Requires Authentication Unlicensed Licensed Download PDF	587
New eye-color mutants affecting the biosynthesis of pteridines and ommochromes in Drosophila melanogaster J. Ferré, D.A. Jacobson and M.T. Calatayud Requires Authentication Unlicensed Licensed Download PDF	591
Search for 6- and 7-biopterins in human saliva T. Sueoka, S. Katoh, T. Sugimoto, S. Matsuura, H. Shintaku and M. Akino Requires Authentication Unlicensed Licensed Download PDF	595
VII. TETRAHYDROBIOPTERIN-DEPENDENT MONOOXYGENASES
Regulation of the aromatic amino acid hydroxylases S. Kaufman Requires Authentication Unlicensed Licensed Download PDF	601
Expression of rat liver dihydropteridine reductase in Escherichia coli J.M. Whiteley, M. Schneider, K. Trach and J. Hoch Requires Authentication Unlicensed Licensed Download PDF	612
Escherichia coli dihydropteridine reductase is a trifunctional enzyme with dihydrofolate reductase activity. Subhash G. Vasudevan and Wilfred L.F. Armarego Requires Authentication Unlicensed Licensed Download PDF	616
Rat liver preparations with glyceryl etherase activity Behjat Kosar-Hashemi and Wilfred L.F. Armarego Requires Authentication Unlicensed Licensed Download PDF	620
Purification and characterization of a membrane associated folate binding protein from human leukemic CCRF-CEM cells J.H. Schornagel, G.A.M. Kathmann, G. Jansen, G.R. Westerhof and G. Rijksen Requires Authentication Unlicensed Licensed Download PDF	624
On the effects of high protein diet and of starvation on phenylalanine hydroxylase activities in rats. J. Donlon, G. A. Walsh and M.P. Carty Requires Authentication Unlicensed Licensed Download PDF	628
Effects of experimental diabetes on phenylalanine hydroxylase activities in rats J. Donlon, G.A. Walsh and K. Howard Requires Authentication Unlicensed Licensed Download PDF	632
Molecular defects of PKU in Italy differ from those of other European countries A. Ponzone, G.B. Ferrero, I. Dianzani, C. Camaschella, M. Devoto, G. Romeo, R. Cerone, C. Romano, M. Giovannini, E. Riva, U. Lichter-Konecki, F.K. Trefz and S.L.C. Woo Requires Authentication Unlicensed Licensed Download PDF	636
The oxidation of tetrahydropteridines by phenylalanine hydroxylase S. Kaufman and M.D. Davis Requires Authentication Unlicensed Licensed Download PDF	640
Interaction of catecholamines and tetrahydropterins with bovine liver phenylalanine hydroxylase J. Haavik, T. Flatmark, G. Dahle, K.K. Andersson and A. Martinez Requires Authentication Unlicensed Licensed Download PDF	644
Studies of tetrahydrobiopterin uptake in rat brain synaptosomes D.M. Kuhn, R.A. Levine, W.A. Wolf and P.Z. Anastasiadis Requires Authentication Unlicensed Licensed Download PDF	648
The influence of cofactor side-chain chirality on the activity and regulation of phenylalanine and tyrosine and hydroxylases J.E. Ayling, S.B. Dillard, R.Y. Chandrasekaran and S.W. Bailey Requires Authentication Unlicensed Licensed Download PDF	652
Limited denaturation stimulates tetrahydrobiopterin-dependent activity of rat liver phenylalanine hydroxylase Michael A. Parniak Requires Authentication Unlicensed Licensed Download PDF	656
Effect of limited proteolysis on structure and activity of phenylalanine hydroxylase Michael A. Parniak Requires Authentication Unlicensed Licensed Download PDF	660
Tetrahydropterin as a possible natural cofactor in the Drosophila phenylalanine hydroxylation system J. Ferre, K.B. Jacobson and Y. Bel Requires Authentication Unlicensed Licensed Download PDF	664
Interaction of substrate analog inhibitors with rat liver dihydropteridine reductase J.M. Whiteley, S. Webber and T. Bray Requires Authentication Unlicensed Licensed Download PDF	668
Simultaneous purification of phenylalanine hydroxylase, phenylalanine hydroxylase stimulator protein, and dihydropteridine reductase from rat liver Michael A. Parniak Requires Authentication Unlicensed Licensed Download PDF	672
VIII. FOLATES
A. DIHYDROFOLATE REDUCTASE
NMR and mutagenesis studies of dihydrofolate reductase G. C. K. Roberts Requires Authentication Unlicensed Licensed Download PDF	681
Spectroscopic studies of the interaction of ligands with dihydrofolate reductase Geeta Maharaj, James R. Appleman, Raymond L. Blakley, Robert E. London, Michael E. Perlman, Barry S. Selinsky, James H. Freisheim, Tavner J. Delcamp, John A. Montgomery and James R. Piper Requires Authentication Unlicensed Licensed Download PDF	694
Comparison between human and bacterial dihydrofolate reductase structures C. Oefner, D. Stüber, K. Müller, A. D’Arcy and F. K. Winkler Requires Authentication Unlicensed Licensed Download PDF	702
Mutagenesis of human dihydrofolate reductase structure as a probe of enzyme function T.J. Delcamp, P. Thompson, A.M.E. Bullerjahn, P.L. Smith, X. Tan, N.J. Prendergast, S. Huang, J . H . Freisheim, R.L. Blakley, J.-T. Tsay, W.A. Beard and J.R. Appleman Requires Authentication Unlicensed Licensed Download PDF	708
Folate and dihydrofolate reduction by mouse dihydrofolate reductase J. Thillet, S. J. Benkovic and J. Adams Requires Authentication Unlicensed Licensed Download PDF	716
Kinetic mechanism of recombinant human dihydrofolate reductase Raymond L. Blakley, William A. Beard, James R. Appleman, James H. Freisheim, Tavner J. Delcamp and Neil J. Prendergast Requires Authentication Unlicensed Licensed Download PDF	722
The kinetic mechanism of the reaction catalyzed by an R-plasmid (R-67) dihydrofolate reductase from E.coli. M.K. Sneddon and J.F. Morrison Requires Authentication Unlicensed Licensed Download PDF	728
Mechanism based inhibitors of dihydrofolate reductase. H.C.S. Wood, C.J. Suckling, L. Rees and J. McGill Requires Authentication Unlicensed Licensed Download PDF	734
Trimetrexate resistant L. casei and S. faecium L.E. Freeberg and T. Tamura Requires Authentication Unlicensed Licensed Download PDF	740
Second site revertants of E. coli dihydrofolate reductase J. Artman, L. Reece, C. Linn and E. Howell Requires Authentication Unlicensed Licensed Download PDF	744
Structural and energetic aspects of the reaction pathway and transition state for hydride-ion transfer in dihydrofolate reductase J.E. Gready and P.L. Cummins Requires Authentication Unlicensed Licensed Download PDF	748
Cloning of trimethoprim-resistant dihydrofolate reductase from multiresistant staphylococci and expression in E. coli R.L. Then and A. Burdeska Requires Authentication Unlicensed Licensed Download PDF	752
Role of TRP-24 in binding and catalysis for human dihydrofolate reductase (DHFR) R. L. Blakley, J. R. Appleman, W. A. Beard, J. H. Freisheim, T. J. Delcamp and S. Huang Requires Authentication Unlicensed Licensed Download PDF	756
Mutation at hydrophobic residues in dihydrofolate reductase Joseph R. Bertino, Matthias Volkenandt, Adam Dicker, Helena Gritsman and Barry I. Schweitzer Requires Authentication Unlicensed Licensed Download PDF	760
Determination of the functional role of phenylalanine-31 of recombinant human dihydrofolate reductase by site-directed mutagenesis R. L. Blakley, W. A. Beard, J. R. Appleman, J.-T. Tsay, J. Freisheim, T. J. Delcamp and N. Prendergast Requires Authentication Unlicensed Licensed Download PDF	765
Molecular modeling studies and crystal structure determination of pteridine antifolate-DHFR enzyme interactions Joseph Luft and Vivian Cody Requires Authentication Unlicensed Licensed Download PDF	769
Allelic variants of Chinese hamster dihydrofolate reductase M.M. Jastreboff and P.W. Melera Requires Authentication Unlicensed Licensed Download PDF	773
B: THYMIDYLATE SYNTHASE
Thymidylate synthase - structural and functional considerations C.A. Janson, W. W. Smith, X.E. Villafranca and D.A. Matthews Requires Authentication Unlicensed Licensed Download PDF	781
Defining the catalytic role of specific amino acids in thymidylate synthase by site-specific mutagenesis G. F. Maley, V. Frasca, L. LaPat-Polasko and F. Maley Requires Authentication Unlicensed Licensed Download PDF	795
Studies of the effects of mutagenesis on a conserved active site arginine residue in thymidylate synthase L. F. Johnson, H. Zhang, R. B. Dunlap, J. W. Zapf, W. Deng, R. J. Cisneros, D. L. Matthews and J. E. Villafranca Requires Authentication Unlicensed Licensed Download PDF	805
Dual role of serine hydroxymethyltransferase in the synergy of fluorouracil and leucovorin: effects of L-serine and glycine on H₄PteGlu/5,10-CH₂-H₄PteGlu ratios; and H₄PteGlu-catalyzed release of fluoride ion from alpha-fluoro-beta alanine. S. Granger, M. Ray, C.P. Spears, R.B. Diasio and B.G. Gustavsson Requires Authentication Unlicensed Licensed Download PDF	811
Interaction of N⁴-hydroxy-dCMP and N⁴-hydroxy-5-FdCMP with L1210 thymidylate synthase differing in sensitivity towards 5- FdUMP Inhibition W. Rode, J.M. Dzik, Z. Zielihski, M. Bretner, T. Kulikowski, D. Shugar and B. Kierdaszuk Requires Authentication Unlicensed Licensed Download PDF	817
Mechanism of thymidylate synthase inhibition by N⁴-Hydroxy-dCMP W. Rode, Z. Zielinski, J.M. Dzik, M. Bretner, T. Kulikowski, D. Shugar and B. Kierdaszuk Requires Authentication Unlicensed Licensed Download PDF	821
Thymidylate synthase activity in bronchoalveolar lavage cells as a possible marker in lung cancer diagnosis J. Ciefcla, Z. Zielihski, W. Rode, W. Droszcz, E. Wałajtys-Rode, H. Grubek-Jaworska and A. Lasota Requires Authentication Unlicensed Licensed Download PDF	825
Purification and properties of Hymenolepis diminuta and regenerating rat liver thymidylate synthases W. Rode, J. Ciefcla, B. Rzeszotarska, K. Pawelczak, M. Kempny and B. Machnicka Requires Authentication Unlicensed Licensed Download PDF	829
Influence of FdUMP on the binding of methotrexate to thymidylate synthase C. Briand, J.C. Sari, C. Lopez and R. Gilli Requires Authentication Unlicensed Licensed Download PDF	833
Efficient expression of mammalian thymidylate synthase in Escherichia coli L. F. Johnson, H. Zhang, R. B. Dunlap and R. J. Cisneros Requires Authentication Unlicensed Licensed Download PDF	836
Catalytic role of histidine-147 in Escherichia coli thymidylate synthase Walter S. Dallas, Julie Atashi, Barbara B. Yates and Inderjit K. Dev Requires Authentication Unlicensed Licensed Download PDF	840
Variation among human thymidylate synthase enzymes in folate affinity S.H. Berger and S.T. Davis Requires Authentication Unlicensed Licensed Download PDF	844
Evaluation of in vivo inhibition of thymidylate synthase in patients with colorectal cancer treated with 5-fluorouracil H.M. Pinedo, S. Meijer, C.L. van der Wilt, E. Laurensse, C.J. vein Groeningen and G.J. Peters Requires Authentication Unlicensed Licensed Download PDF	848
Effect of leucovorin on 5-fluorouracil induced inhibition of thymidylate synthase in murine colon cancer G.J. Peters, H.M. Pinedo and C.L. van der Wilt Requires Authentication Unlicensed Licensed Download PDF	852
Feedback inhibition of thymidylate synthase by dihydrofolate polyglutamates cannot account for partial depletion of tetrahydrofolate cofactors by antifolates I.D. Goldman, D.F. Trent and R.L. Seither Requires Authentication Unlicensed Licensed Download PDF	856
Kinetic studies on thymidylate synthase from Lactobacillus casei R. G. Matthews, R. Oleinick, C. Ghose and R. B. Dunlap Requires Authentication Unlicensed Licensed Download PDF	860
C. METHIONINE SYNTHASE
Studies on the cobalamin-dependent methionine synthase from Escherichia coli K12 Rowena G. Matthews and Ruma V. Banerjee Requires Authentication Unlicensed Licensed Download PDF	869
Foimyl phosphate as an intermediate in the N¹⁰-formyltetrahydrofolate synthetase reaction. R.H. Himes, H. Jahansouz and M.R. Mejillano Requires Authentication Unlicensed Licensed Download PDF	873
Enzymes of homocysteine remethylation and transsulfuration in methionine or cholesterol induced atherosclerosis in rabbits B. Grzelakowska-Sztabert, E. Sikora, M. Manteuffel-Cymborowska, W. Chmurzynska and M. Toborek Requires Authentication Unlicensed Licensed Download PDF	877
Biochemical changes in porcine neural tissue after inactivation of methionine synthase by nitrous oxide. D.G. Weir, J.M. Scott, J. Keating, A.M. Molloy, D. Rice, S. Kennedy and G. Kennedy Requires Authentication Unlicensed Licensed Download PDF	881
Increased synthesis of AdoMet but not of methionine during testosterone stimulation of polyamine biosynthesis in mouse kidney B. Grzelakowska-Sztabert, W. Chmurzynska and M. Manteuffel-Cymborowska Requires Authentication Unlicensed Licensed Download PDF	885
D. ENZYMOLOGY AND METABOLISM
Role of folylpolyglutamate synthetase in the regulation of folate and antifolate metabolism. B. Lin, J. Kim, C. Osborne, K. Lowe and B. Shane Requires Authentication Unlicensed Licensed Download PDF	891
NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase present in transformed mammalian cells C. Belanger, R.E. MacKenzie, W.P. Sheffield, D.W. Hum and K.G. Peri Requires Authentication Unlicensed Licensed Download PDF	896
Gammaglutamyl hydrolases V. Michael Whitehead Requires Authentication Unlicensed Licensed Download PDF	903
Human methenyltetrahydrofolate synthetase R. Bertrand and J. Jolivet Requires Authentication Unlicensed Licensed Download PDF	910
Folate catabolism in man and the rat D.C. Weir, G. Courtney, H. McNulty, F. Geoghegan, J. McPaitlin and J.M. Scott Requires Authentication Unlicensed Licensed Download PDF	916
Effects of growth rate on y-glutamyl hydrolase in Ehrlich ascites carcinoma cells Ewa Sikora Requires Authentication Unlicensed Licensed Download PDF	922
Folylpolyglutamate synthesis in Neurospora crassa. Wild type FPGS activity and transformation of polyglutamate deficient mutants using cosmid vectors containing the met-6 gene E.A. Cossins, F.E. Nargang, I.J. Atkinson and P.Y. Chan Requires Authentication Unlicensed Licensed Download PDF	926
Cloning and expression of the gene encoding Lactobacillus casei folylpolyglutamate synthetase in Escherichia coli Andrew L. Bognar and Jeffrey Toy Requires Authentication Unlicensed Licensed Download PDF	930
Effect of treatments with different anticonvulsant drugs on folate pattern in rat liver. M. Marchetti, S. Sassi, G. Formiggini and C. Bovina Requires Authentication Unlicensed Licensed Download PDF	934
A sensitive new microassay useful for measurement and purification of mammalian folylpolyglutamate synthetase Richard G. Moran and Bruno Antonsson Requires Authentication Unlicensed Licensed Download PDF	938
Tissue differences in N⁵ formyltetrahydrofolate metabolism D.S. Duch, B.R. Keith and R.J. Mullin Requires Authentication Unlicensed Licensed Download PDF	944
E. FOLATES IN ENDOGENOUS PURINE METABOLISM
Glycinamide ribonucleotide transformylase from E. coli: characterization and inhibition. Stephen J. Benkovic, Dana L. Johnson and James Inglese Requires Authentication Unlicensed Licensed Download PDF	951
Estimation of the flux control coefficient of glycineamide ribonucleotide transformylase for purine biosynthesis de novo R.J. Mullin, M. H. Hanion, M. Salter, C.I. Pogson, R. Knowles and G.K. Smith Requires Authentication Unlicensed Licensed Download PDF	957
Monocyclic 5-deazatetrahydrofolate analogues as inhibitors of de novo purine biosynthesis G. Smith, J. Kelley, R. Ferone, D. Duch and E. Bigham Requires Authentication Unlicensed Licensed Download PDF	961
Inhibition of glycinamide ribonucleotide transformylase, methotrexate transport, and the growth of MCF-7 cells by 5,8-dideazafolates J.B. Hynes, S.J. Benkovic, G.K. Smith, R. Ferone, M.P. Edelstein, D.S. Duch and S.D. Banks Requires Authentication Unlicensed Licensed Download PDF	965
F. FOLATES, VARIOUS
Formation of methylcobamide from methyltetrahydrofolate by acetogenic bacteria: enzymology and redox chemistry. David L. Roberts, Wei-Ping Lu, Scott R. Harder and Stephen W. Ragsdale Requires Authentication Unlicensed Licensed Download PDF	971
Incorporation of the ring carbon of histidine into coenzymes of folylpolyglutamates. T. Brody and E. L. R. Stokstad Requires Authentication Unlicensed Licensed Download PDF	977
In vivo effect of folic acid on fragile-site expression S. Tilkian, P. DeCilla and G. Lefevre Requires Authentication Unlicensed Licensed Download PDF	981
IX. ANTIFOLATES
A. DEAZADERIVATIVES
New synthetic studies on deazafolates Cheol-min Yoon, George S. K. Wong, John C. Warner, Maria Papadopoulou, James M. Hamby, Philip M. Harrington, Zen-yu Chang and Edward C. Taylor Requires Authentication Unlicensed Licensed Download PDF	987
Molecular modeling studies on deazatetrahydrofolates G.B. Grindey, C. Shih, R.G. Moran, P.M. Harrington and E.C. Taylor Requires Authentication Unlicensed Licensed Download PDF	995
Biochemical pharmacology of deazatetrahydrofolates D. Wildman, A.D. Cross, B.A. Moroson, A.R. Cashmore, O. Russello, G. Pizzorno, G.P. Beardsley and G.B. Grindey Requires Authentication Unlicensed Licensed Download PDF	1001
Synthesis and evaluation of l-deaza-7,8-dihydropteridines and ring analogues C. G. Temple Requires Authentication Unlicensed Licensed Download PDF	1009
In vitro and in vivo activity of the GAR transformylase inhibitor 5-deazacyclotetrahydrofolate H.R. Wilson, S. Singer, R.J. Mullin, E.W. McLean, V. Knick, J.L. Kelley, J. Humphreys, L.S. Heath, M.H. Hanlon, R. Ferone, M.P. Edelstein, D.S. Duch, N.K. Cohn, E.C. Bigham, S.D. Banks, G.K. Smith and J. Houghton Requires Authentication Unlicensed Licensed Download PDF	1015
vitro and in vivo studies with 2-desamino-2-CH₃-N¹⁰-propargyl-5,8- dideazafolate (ICI 198583), an inhibitor of thymidylate synthase A.H. Calvert, L.R. Hughes, J.A.M. Bishop, G.A. Taylor, D.I. Jodrell, D.R. Newell and A.L. Jackman Requires Authentication Unlicensed Licensed Download PDF	1023
Comparative studies on the activity of methotrexate and the analog 10-ethyl-10-deaza-aminopterin (10-EdAM) against head and neck carcinoma cell lines and xenografts. G.B. Snow, D.H. Brown, G.A.M.S. van Dongen, B.J.M. Braakhuis and G.J. Peters Requires Authentication Unlicensed Licensed Download PDF	1027
Transport of 5,10-dideazatetrahydrofolic acid (DDATHF) in CCRF-CEM sensitive and methotrexate resistant cell lines G.P. Beardsley, A.D. Cross, A.R. Cashmore, B.A. Moroson and G. Pizzorno Requires Authentication Unlicensed Licensed Download PDF	1031
Synthesis and structure-activity relationship studies of 5,10- dideazatetrahydrofolic acid (DDATHF) L.S. Gossett, G.B. Grindey, C. Shih, R.G. Moran, P.M. Harrington and E.C. Taylor Requires Authentication Unlicensed Licensed Download PDF	1035
Synthesis and antifolate properties of 5-alkyl-5-deazaaminopterin analogues modified in the 10-position J. A. Montgomery, J. R. Piper and F. M. Sirotnak Requires Authentication Unlicensed Licensed Download PDF	1039
Synthesis and biological evaluation of 2-desamino-2-methyl-5,10- dideazatetrahydrofolate M.G. Nair, Y. Gaumont, R.L. Kisliuk and Sharadbala D. Patilt Requires Authentication Unlicensed Licensed Download PDF	1043
Quinazoline antifolate thymidylate synthase inhibitors: potent cytotoxic agents containing heterocyclic isosteres of the para-amino benzoate unit John Oldfield, Anthony J. Hayter, Leslie R. Hughes, Peter R. Marsham, A. Hilary Calvert, Breda M. O’Connor, Joel A. M. Bishop and Ann L. Jackman Requires Authentication Unlicensed Licensed Download PDF	1048
Antifungal activity of some 2,4-diamino-5-methyl-6-alkyl quinazoline A. Cheng, J.A. Lawson, K.J. Ryan, J.I. Degraw and W.T. Colwell Requires Authentication Unlicensed Licensed Download PDF	1052
Membrane transport characteristics of the thymidylate synthase inhibitor 2-desamino-2-methyl-N¹⁰-propargyl-5,8-dideazafolic acid. G.R. Westerhof, J.H. Schornagel, G. Jansen, G. Rijksen, A.L. Jackman and D.R. Newell Requires Authentication Unlicensed Licensed Download PDF	1056
Synthesis and potential antitumor activity of 5-deaza analogs of 5,10- methylenetetrahydrofolic acid J. Patel, A. Gangjee, Y. Gaumont and R.L. Kisliuk Requires Authentication Unlicensed Licensed Download PDF	1060
Theoretical studies of the structures and conformations of triazine antifolates L.R. McMillan and W.J. Welsh Requires Authentication Unlicensed Licensed Download PDF	1064
In vitro and in vivo metabolism of 5-DACTHF, an acyclic tetrahydrofolate analog B.R. Keith, R.J. Mullin, R. Ferone and M.H. Hanlon Requires Authentication Unlicensed Licensed Download PDF	1068
Measurement of retained thymidylate synthase (TS) inhibition by antifolates in whole cells in vitro L.R. Hughes, P.R. Marsham, J.A.M. Bishop, A.H. Calvert, K. Balmanno, A.L. Jackman and G.A. Taylor Requires Authentication Unlicensed Licensed Download PDF	1072
Substitution on the benzene ring of quinazoline antifolates that inhibit thymidylate synthase P. Marsham, A.J. Barker, J.M. Wardleworth, J. Oldfield, L.R. Hughes, A.H. Calvert, G. Bisset, J.A.M. Bishop, B.M. O’Connor, T. Thornton and A.L. Jackman Requires Authentication Unlicensed Licensed Download PDF	1076
Inhibition of de novo purine synthesis by deazatetrahydrofolates E.C. Taylor, C. Shih, S.W. Baldwin and R.G. Moran Requires Authentication Unlicensed Licensed Download PDF	1080
B.Methotrexates
Resistance to methotrexate in experimental models and in patients B. Schweitzer, J.T. Lin, M. Volkenandt, A. Dicker, A. Romanini and J.R. Bertino Requires Authentication Unlicensed Licensed Download PDF	1089
Methotrexate peptides as cancer chemotherapeutic agents K.S. Vitols, Y. Montejano, J. Fan, A. Esswein, U. Kuefner and F.M. Huennekens Requires Authentication Unlicensed Licensed Download PDF	1100
Biochemical determinants of methotrexate selectivity R.L. Capizzi, T.E. Kute, P Sur and D.J. Femandes Requires Authentication Unlicensed Licensed Download PDF	1110
Mechanisms underlying methotrexate inactivity in human head and neck cancer xenografts G. Jansen, A. Leyva, G.J. Peters, G.B. Snow, G.A.M.S. van Dongen and B.J.M. Braakhuis Requires Authentication Unlicensed Licensed Download PDF	1119
Design and synthesis of novel methotrexate derivatives for antibody directed drug targeting R.W. Baldwin, M.C. Gamett and T.H. Khan Requires Authentication Unlicensed Licensed Download PDF	1123
Methotrexate (MTX) transport and cytotoxity of MTX and trimetrexate (TMQ) for human squamous cell carcinoma (SCC) of the head and neck grown at low folate concentrations Rijksen G., J.H. Schomagel, G.R. Westerhof, G.A.M. Kathmann, J.A. van Gestel, G. Jansen, G.J. Hordijk and B.F.A.M. van der Laan Requires Authentication Unlicensed Licensed Download PDF	1127
Folate enhancement of antifolate synergism in lymphoma cells M.G. Nair, J.R. Piper, R. Emkey, R.L. Kisliuk and Y. Gaumont Requires Authentication Unlicensed Licensed Download PDF	1131
Amino acid oxidation and dihydrofolate reductase inactivation photosensitized by a diaminopteridine A. Valla, R. Santus and M. Aubailly Requires Authentication Unlicensed Licensed Download PDF	1137
Synchronisation of U937 and SW626 cancer cell lines of human origin using methotrexate M. D’Incalci, E. Erba and S. Sen Requires Authentication Unlicensed Licensed Download PDF	1141
New inhibitors of plasmodial folate synthesis - comparison of cell-free, whole cell and in vivo activities for single drugs and drug combinations S. Chandra, R. Walter, J.K. Seydel, K.J. Schaper, B. Kunz, M. Kansy and M. Wiese Requires Authentication Unlicensed Licensed Download PDF	1145
Effect of vincristine on methotrexate cytotoxicity and accumulation in MCF-7 cells, a human breast cancer cell line F. Mandelbaum-Shavit Requires Authentication Unlicensed Licensed Download PDF	1150
The y-tetrazole analog of methotrexate: design, synthesis and biological activity J.J. McGuire, C.A. Russel, A.M. Yawman, C.S. Jones and T.I. Kalman Requires Authentication Unlicensed Licensed Download PDF	1154
Effect of intravenous 24 hr infusions of methotrexate on unconjugated pteridine metabolism J.P. Farriaux, B. Dupriez, F. Mazingue, F. Millot, J.M. Hayte and J.L. Dhondt Requires Authentication Unlicensed Licensed Download PDF	1158
Covalent labeling of dihydrofolate reductase and folate transport proteins by fluorescein methotrexate F.M. Huennekens, K.S. Vitols, L.E. Pope and J. Fan Requires Authentication Unlicensed Licensed Download PDF	1162
Study of methotrexate polyglutamate formation in cultured leukemic cells T.I. Kalman, C. Hucal, C. Payment, M.J. Vuchich and V.M. Whitehead Requires Authentication Unlicensed Licensed Download PDF	1166
C. Various Antifolates
Folyl polyglutamates in metabolism and chemotherapy R.L. Kisliuk Requires Authentication Unlicensed Licensed Download PDF	1173
Biological determination of selective antitumor action of 4-amino-folate analogs B. Rumberger, J.R. Barrueco and F.M. Sirotnak Requires Authentication Unlicensed Licensed Download PDF	1185
Inhibition of the thymidylate synthase cycle of leukemia cells by antifolates: The usefulness of the cellular tritium release assay T.I. Kalman Requires Authentication Unlicensed Licensed Download PDF	1192
Fluoroglutamate-containing folates and antifols: probing the role of polyglutamylation in vitro J. Galivan, J.J. McGuirc and J.K. Coward Requires Authentication Unlicensed Licensed Download PDF	1198
Therapeutic strategies for 5-fluorouracil-leucovorin based upon cellular metabolic characteristics in human colon adenocarcinoma xenografts S.S.N. de Graaf, P.J. Houghton, P.J. Cheshire, L.G. Williams and J.A. Houghton Requires Authentication Unlicensed Licensed Download PDF	1203
The lack of response of human colonic tumor cell lines to biochemical modulation by folinic acid. S.H. Berger and C.T. Hughey Requires Authentication Unlicensed Licensed Download PDF	1209
Folinic acid as a source of intracellular 5,10-methylenetetrahydrofolate in human carcinoma cells S.H. Berger and D.H. Eagerton Requires Authentication Unlicensed Licensed Download PDF	1213
Structure activity relationships of multidrug resistance T.A. Khwaja, C. Hansch and C.D. Selassie Requires Authentication Unlicensed Licensed Download PDF	1217
Enhancement of the cytotoxicity of fluoropyrimidines to human carcinoma cell lines by leucovorin K.L. Scanlon and R.G. Moran Requires Authentication Unlicensed Licensed Download PDF	1221
D. Transport And Absorption Of Folates And Antifolates
Methotrexate transport via the high-affinity folate binding protein of L1210 cells. B.P. Strauss and G.B. Henderson Requires Authentication Unlicensed Licensed Download PDF	1227
Combined affinity and ion pair liquid chromatographies for direct analysis of tissue folate composition Jacob Selhub Requires Authentication Unlicensed Licensed Download PDF	1238
Tumor cell sensitivity and resistance to folate analogues: the role of carrierand receptor-mediated transport systems J.H. Schomagel and G. Jansen Requires Authentication Unlicensed Licensed Download PDF	1247
Lysosomal permeability to methotrexate polyglutamates F.M. Sirotnak and J.R. Barrueco Requires Authentication Unlicensed Licensed Download PDF	1253
Folic acid metabolism in placental cells associated with neural tube defects C.J. Schorah, R.W. Smithells and N. Habibzadeh Requires Authentication Unlicensed Licensed Download PDF	1257
Homologous membrane folate binding proteins in human placenta J.H. Freisheim, J.L. Duhring, H. Marquardt, P.L. Smith, A.M.E. Bulleijahn, T.P. McAlinden and M. Ratnam Requires Authentication Unlicensed Licensed Download PDF	1262
A high-affinity folate binding protein in human amniotic fluid M. Hoier-Madsen, S.I. Hansen and J. Holm Requires Authentication Unlicensed Licensed Download PDF	1268
Interaction of N-hydroxy(sulfo)succinimide active esters with the reduced folate/methotrexate transport system from human CCRF-CEM leukemia cells G. Rijksen, J.H. Schomagel, G.A.M. Kathmann, G.R. Westerhof and G. Jansen Requires Authentication Unlicensed Licensed Download PDF	1272
Renal uptake and metabolism of 5-methyltetrahydrofolate in the rat T.D. Collins, B.H. Eisenga and K.E. McMartin Requires Authentication Unlicensed Licensed Download PDF	1276
Methotrexate- and folate-lipid conjugates of defined chemical structures as new antifolate analogs and transport probes H. Ringsdorf, M. Ahlers, M. Przybylski and T. Knepper Requires Authentication Unlicensed Licensed Download PDF	1280
Characterization of receptor-mediated (anti)folate uptake in human CCRF-CEM cells G. Rijksen, J.H. Schomagel, G.A.M. Kathmann, G. Jansen and G.R. Westerhof Requires Authentication Unlicensed Licensed Download PDF	1284
Author Index Requires Authentication Unlicensed Licensed Download PDF	1289
Subject Index Requires Authentication Unlicensed Licensed Download PDF	1297
List of Participants Requires Authentication Unlicensed Licensed Download PDF	1319
Backmatter Requires Authentication Unlicensed Licensed Download PDF	1341

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Pages and Images/Illustrations in book

eBook published on:

October 8, 2019

eBook ISBN:

9783110889000

Hardcover published on:

July 1, 1990

Hardcover ISBN:

9783110121995

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Reprint 2019

Pages and Images/Illustrations in book

Front matter:

36

Main content:

1340

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https://doi.org/10.1515/9783110889000

eBook ISBN: 9783110889000

Hardcover ISBN: 9783110121995

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Walter de Gruyter GmbH
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9 Zurich, Switzerland, September 3–8, 1989

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