Frontmatter

Chapters in this book

1. Frontmatter I
2. Preface V
3. Contents VII
4. 1 Nucleosides: structure, nomenclature and solution equilibria 1
5. 2 Nucleosides: synthesis, reactions and use in chemotherapy 31
6. 3 Nucleotides 63
7. 4 Oligonucleotides: synthesis 93
8. 5 Oligonucleotides: reactions of phosphodiester linkages 145
9. 6 Oligonucleotide conjugates 175
10. 7 Nucleic acids 195
11. 8 Catalytic nucleic acids 241
12. 9 Nucleic acids as drugs and drug targets 1: antisense, splice-switching, triplex-forming and immune-stimulatory oligonucleotides 267
13. 10 Nucleic acids as drugs and drug targets 2: RNA interference, 2′,5′-oligoadenylates and riboswitches 291
14. 11 Nucleic acids as drugs and drug targets 3: target recognition and delivery 309
15. Abbreviations 343
16. Index 347