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4 Oligonucleotides: synthesis
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Harri Lönnberg
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Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
- 1 Nucleosides: structure, nomenclature and solution equilibria 1
- 2 Nucleosides: synthesis, reactions and use in chemotherapy 31
- 3 Nucleotides 63
- 4 Oligonucleotides: synthesis 93
- 5 Oligonucleotides: reactions of phosphodiester linkages 145
- 6 Oligonucleotide conjugates 175
- 7 Nucleic acids 195
- 8 Catalytic nucleic acids 241
- 9 Nucleic acids as drugs and drug targets 1: antisense, splice-switching, triplex-forming and immune-stimulatory oligonucleotides 267
- 10 Nucleic acids as drugs and drug targets 2: RNA interference, 2′,5′-oligoadenylates and riboswitches 291
- 11 Nucleic acids as drugs and drug targets 3: target recognition and delivery 309
- Abbreviations 343
- Index 347
Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
- 1 Nucleosides: structure, nomenclature and solution equilibria 1
- 2 Nucleosides: synthesis, reactions and use in chemotherapy 31
- 3 Nucleotides 63
- 4 Oligonucleotides: synthesis 93
- 5 Oligonucleotides: reactions of phosphodiester linkages 145
- 6 Oligonucleotide conjugates 175
- 7 Nucleic acids 195
- 8 Catalytic nucleic acids 241
- 9 Nucleic acids as drugs and drug targets 1: antisense, splice-switching, triplex-forming and immune-stimulatory oligonucleotides 267
- 10 Nucleic acids as drugs and drug targets 2: RNA interference, 2′,5′-oligoadenylates and riboswitches 291
- 11 Nucleic acids as drugs and drug targets 3: target recognition and delivery 309
- Abbreviations 343
- Index 347
