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book: Animal Cell Biotechnology
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Animal Cell Biotechnology

In Biologics Production
  • Edited by: Hansjörg Hauser and Roland Wagner
Language: English
Published/Copyright: 2014
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About this book

This book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell cultures. A broad spectrum of subjects relevant to biologics production and manufacturing are reviewed, including the generation of robust cell lines, a survey of functional genomics for a better understanding of cell lines and processes, as well as advances in regulatory compliant upstream and downstream development. The book is an essential reference for all those interested in translational animal cell-based pharmaceutical biotechnology.

  • Animal cells for the industrial manufacturing of recombinant proteins and virus-based biologics
  • Includes latest scientific and technological aspects from gene(s) to warehouse
  • Full color illustrations

Author / Editor information

Hansjörg Hauser, Helmholtz Centre for Infection Research, Braunschweig; Roland Wagner, Rentschler Biotechnologie GmbH, Laupheim

Supplementary Materials


Publicly Available Download PDF
I

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V

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VII

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IX
1. Introduction

Roland Wagner and Hansjörg Hauser
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1
2. Cell Lines

Christoph Lipps, Tobias May and Dagmar Wirth
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11

Florian M. Wurm
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38

Ingo Jordan and Volker Sandig
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60

Roderick A. F. MacLeod and Hans G. Drexler
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87

Wilhelm G. Dirks and Cord C. Uphoff
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102
3. Genetic Engineering of Cells

Hitto Kaufmann
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115

Takeshi Omasa and Kyoungho Lee
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127

David Ausländer and Martin Fussenegger
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144

Natascha Kruse, Shawal Spencer and Dagmar Wirth
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173

Hans Henning von Horsten, Karsten Winkler and Volker Sandig
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216
4. Engineering of the Product

Sandra V. Bennun, Kelley M. Heffner, Emily Blake, Andrew Chung and Michael J. Betenbaugh
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247

Lore Florin, Sören K. Rasmussen, Torben P. Frandsen and Anne B. Tolstrup
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280
5. Basic Aspects of Animal Cell Cultivation

Venkata Tayi and Michael Butler
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301

Karina Brinkrolf, Raimund Hoffrogge, Matthias Hackl, Andreas Tauch, Martina Baumann, Thomas Noll, Alexander Goesmann, Alfred Pühler and Nicole Borth
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326

Claudia Altamirano, Julio Berrios and Mauricio Vergara
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368
6. Upstream and Downstream Process Technology

Detlef Eisenkraetzer
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389

Natalia Ceaglio, Mariela Bollati-Fogolín, Marcos Oggero, Marina Etcheverrigaray and Ricardo Kratje
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427

Weiwei Hu and Kelly Wiltberger
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455

Nuno Fontes, Ruoheng Zhang and Jens H. Vogel
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489
7. Monitoring and Control of Processes and Products

John Paul Smelko, Thomas Ryll and Dethardt Müller
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523

Amy Hong Que, Yang Wang and Steven Ziyi Kan
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571

Vijay Janakiraman, Matthew Westoby and Lynn Conley
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598
8. Pharmaceutical Aspects of Biologics from Animal Cell Culture Processes

Balder Rebmann, Peter van Hoogevest, Matias Zurbriggen and Wilfried Weber
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649

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693

Publishing information
Pages and Images/Illustrations in book
eBook published on:
November 10, 2014
eBook ISBN:
9783110278965
Hardcover published on:
October 28, 2014
Hardcover ISBN:
9783110278866
Pages and Images/Illustrations in book
Front matter:
15
Main content:
702
Coloured Illustrations:
171
Tables:
30
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