1.1 Extracellular matrix: a functional scaffold

Chapters in this book

1. Frontmatter i
2. Contents v
3. Preface xix
4. Comments on the book Extracellular Matrix: Pathobiology & Signaling xxiii
5. About the Editor/Section Editors xxv
6. List of contributing authors xxix
7. Abbreviations and acronyms used xxxix
8. 1 An introduction to the extracellular matrix molecules and their importance in pathobiology and signaling
9. 1.1 Extracellular matrix: a functional scaffold 3
10. 2 Insights into the function of glycans
11. 2.1 Introduction 23
12. 2.2 Metabolic control of hyaluronan synthesis 26
13. 2.3 Multiple roles of hyaluronan as a target and modifier of the inflammatory response 39
14. 2.4 Roles of sulfated and nonsulfated glycosaminoglycans in cancer growth and progression-therapeutic implications 66
15. 2.5 Heparan sulfate design: regulation of biosynthesis 84
16. 2.6 Bone and skin disorders caused by a disturbance in the biosynthesis of chondroitin sulfate and dermatan sulfate 98
17. 2.7 Biological functions of branched N-glycans related to physiology and pathology of extracellular matrix 119
18. 3 Proteoglycans: structure, pathobiology, and signaling
19. 3.1 Introduction 135
20. 3.2 Aggrecan in skeletal development and regenerative medicine 141
21. 3.3 The pathobiology of versican 154
22. 3.4 The biology of perlecan and its bioactive modules 171
23. 3.5 Small leucine-rich proteoglycans: multifunctional signaling effectors 185
24. 3.6 Structure and function of syndecans 197
25. 3.7 The glypican family 209
26. 3.8 Serglycin proteoglycan: implications for thrombosis, inflammation, atherosclerosis, and metastasis 221
27. 4 Matrix Proteinases: biological significance in health and disease
28. 4.1 Introduction 235
29. 4.2 Extracellular functions of cysteine proteases 239
30. 4.3 Plasmin and the plasminogen activator system in health and disease 261
31. 4.4 Matrix metalloproteinase complexes and their biological significance 291
32. 4.5 The ADAMTS family of metalloproteinases 315
33. 4.6 Proteinases in wound healing 343
34. 4.7 Rock, paper, and molecular scissors: regulating the game of extracellular matrix homeostasis, remodeling, and inflammation 377
35. 5 ECM cell surface receptors
36. 5.1 Introduction 403
37. 5.2 Integrin function in heart fibrosis: mechanical strain, transforming growth factor-beta 1 activation, and collagen glycation 406
38. 5.3 Cancer-associated fibroblast integrins as therapeutic targets in the tumor microenvironment 432
39. 5.4 Discoidin domain receptors: non-integrin collagen receptors on the move 451
40. 5.5 Syndecans as receptors for pericellular molecules 467
41. 5.6 CD44: a Sensor of tissue damage critical for restoring homeostasis 484
42. 6 Collagens: insights into the folding, assembly and functions
43. 6.1 Introduction 501
44. 6.2 Trimerization domains in collagens: chain selection, folding initiation, and triple-helix stabilization 506
45. 6.3 Structural basis of collagen missense mutations 521
46. 6.4 Roles and regulation of BMP1/Tolloid-like proteinases: collagen/matrix assembly, growth factor activation, and beyond 539
47. 6.5 Supramolecular assembly of type I collagen 562
48. 6.6 Collagen interactomes: mapping functional domains and mutations on fibrillar and network-forming collagens 575
49. 6.7 Collagen-binding proteins 592
50. 7 Emerging aspects in extracellular matrix pathobiology
51. 7.1 Introduction 605
52. 7.2 Extracellular matrix in breast cancer: permissive and restrictive influences emanating from the stroma 610
53. 7.3 EMMPRIN/CD147: potential functions in tumor microenvironment and therapeutic target for human cancer 626
54. 7.4 Implication of hyaluronidases in cancer growth, metastasis, diagnosis, and treatment 639
55. 7.5 Structure-function relationship of syndecan-1, with focus on nuclear translocation and tumor cell behavior 653
56. 7.6 Serglycin: a novel player in the terrain of neoplasia 677
57. 7.7 Quantifying cell-ECM pathobiology in 3D 689
58. 7.8 Diabetic foot infections 703
59. 8 Targeting tumor microenvironment at the ECM level
60. 8.1 Introduction 719
61. 8.2 Targeting the tumor microenvironment in cancer progression 723
62. 8.3 Growth factor signaling and extracellular matrix 741
63. 8.4 Targeting protein-glycan interactions at cell surface during EMT and hematogenous metastasis: consequences on tumor invasion and metastasis 763
64. 8.5 Pharmacological targeting of proteoglycans and metalloproteinases: an emerging aspect in cancer treatment 785
65. 8.6 Targeting syndecan shedding in cancer 802
66. 8.7 PG receptors with phosphatase action in cancer and angiogenesis 813
67. 8.8 Heparanase, a multifaceted protein involved in cancer, chronic inflammation, and kidney dysfunction 824
68. 8.9 Delivery systems targeting cancer at the level of ECM 855
69. Index 873