Abstract
Objective: To compare the frequency of histologic chorioamnionitis and funisitis among women experiencing preterm labor, preterm premature rupture of membranes (PROM) and cervical insufficiency.
Methods: This retrospective cohort study included singleton pregnant women who delivered at ≤36 weeks of gestation. The patients with preterm birth were subdivided into preterm labor (n=117), preterm PROM (n=153), and cervical insufficiency (n=20). All placentas were examined for pathology, according to the criteria of Salafia with minor modification. Frequencies of histologic chorioamnionitis and funisitis were evaluated according to the causes of preterm birth.
Results: 1) Histologic chorioamnionitis was diagnosed in 48.7% (57/117) of cases with preterm labor, 47.4% (73/153) with preterm PROM, and 75.0% (15/20) with cervical insufficiency. Funisitis was detected in 11.1% (13/117) of cases with preterm labor, 15.7% (24/153) with preterm PROM, and 40.0% (8/20) with cervical insufficiency. 2) Frequency of histologic chorioamnionitis was higher in cases with cervical insufficiency compared to preterm PROM. Frequency of funisitis was higher in cases with cervical insufficiency compared to both preterm labor and preterm PROM (P<0.05). The difference in frequency of funisitis remained significant after adjustment for gestational age at delivery and cervical dilatation at diagnosis. 3) Frequency of grade 2 funisitis was higher in cases with cervical insufficiency (35.0%, 7/20) compared to both preterm labor (6.8%, 8/117) and preterm PROM (9.8%, 15/153) (P=0.001). And the difference remained significant after adjustment for gestational age at delivery and cervical dilatation at diagnosis.
Conclusion: The highest frequency of funisitis was observed in cervical insufficiency among cases with spontaneous preterm birth.
References
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The authors stated that there are no conflicts of interest regarding the publication of this article.
Article note:
This was presented at the 35th Annual Meeting of the Society for Maternal-Fetal Medicine, San Diego, CA, February 2–7, 2015.
©2016 by De Gruyter
Articles in the same Issue
- Frontmatter
- Editorial
- Preventing preterm birth
- Original articles
- Vertically transmitted cytomegalovirus infection in newborn preterm infants
- Computerized vital signs analysis and late onset infections in extremely low gestational age infants
- Oral propranolol in early stages of retinopathy of prematurity
- Changes in incidence of iatrogenic and spontaneous preterm births over time: a population-based study
- Predictive factors for preterm delivery under rural conditions in post-tsunami Banda Aceh
- Early pregnancy serum neopterin concentrations predict spontaneous preterm birth in asymptomatic pregnant women
- Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes
- Amniotic fluid LPCAT1 mRNA correlates with the lamellar body count
- Recommendation and Guidelines for Perinatal Practice
- Fetal magnetic resonance imaging and ultrasound
- Original articles - Obstetrics
- Relationship between first-trimester serum placental protein-13 and maternal characteristics, placental Doppler studies and pregnancy outcome
- Higher D-dimer level in the early third trimester predicts the occurrence of postpartum hemorrhage
- Extra-abdominal removal of placenta during cesarean section: a prospective randomized controlled trial of a novel technique
- Correlation of intrapartum translabial ultrasound parameters with computed tomographic 3D reconstruction of the female pelvis
- Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit
- Original articles - Fetus
- Is there a sex difference in fetal behavior? A comparison of the KANET test between male and female fetuses
- Determination of antepartum and intrapartum risk factors associated with neonatal intensive care unit admission
- Short communication
- A guide on how to build a novel home-made part task training simulator for cervical cerclage training
- Congress Calendar
- Congress Calendar
Articles in the same Issue
- Frontmatter
- Editorial
- Preventing preterm birth
- Original articles
- Vertically transmitted cytomegalovirus infection in newborn preterm infants
- Computerized vital signs analysis and late onset infections in extremely low gestational age infants
- Oral propranolol in early stages of retinopathy of prematurity
- Changes in incidence of iatrogenic and spontaneous preterm births over time: a population-based study
- Predictive factors for preterm delivery under rural conditions in post-tsunami Banda Aceh
- Early pregnancy serum neopterin concentrations predict spontaneous preterm birth in asymptomatic pregnant women
- Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes
- Amniotic fluid LPCAT1 mRNA correlates with the lamellar body count
- Recommendation and Guidelines for Perinatal Practice
- Fetal magnetic resonance imaging and ultrasound
- Original articles - Obstetrics
- Relationship between first-trimester serum placental protein-13 and maternal characteristics, placental Doppler studies and pregnancy outcome
- Higher D-dimer level in the early third trimester predicts the occurrence of postpartum hemorrhage
- Extra-abdominal removal of placenta during cesarean section: a prospective randomized controlled trial of a novel technique
- Correlation of intrapartum translabial ultrasound parameters with computed tomographic 3D reconstruction of the female pelvis
- Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit
- Original articles - Fetus
- Is there a sex difference in fetal behavior? A comparison of the KANET test between male and female fetuses
- Determination of antepartum and intrapartum risk factors associated with neonatal intensive care unit admission
- Short communication
- A guide on how to build a novel home-made part task training simulator for cervical cerclage training
- Congress Calendar
- Congress Calendar