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Plasmacytoid dendritic cells and autoimmune inflammation

  • Georgina Galicia

    Georgina Galicia completed her PhD at Catholic University of Leuven, Belgium where she studied experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Dr. Galicia then moved to Toronto to continue her studies in the Department of Immunology at the University of Toronto. Upon joining the Gommerman lab, Dr. Galicia won a post-doctroral fellowship from the MS Society of Canada. Currently Dr. Galicia investigates the immunopathology of EAE, with particular focus on cells of immune cells such as plasmacytoid dendritic cells (pDC) and B cells.

    and Jennifer L. Gommerman

    Jen Gommerman received her PhD in 1998 from the Department of Immunology at the University of Toronto. She went on to do a post-doctoral fellowship with Dr. Michael Carroll at Harvard Medical School and subsequently joined Biogen Idec as a staff scientist under the direction of Dr. Jeffrey Browning. Dr. Gommerman returned to Toronto in 2003 to establish her laboratory in the Department of Immunology at the University of Toronto. She has received funding from the Canadian Institutes of Health Research, the MS Society of Canada and the Kidney Foundation to study the immune system in the context of health and disease. Her funding from the MS Society has allowed her to examine the role of different immune cell types in the immunopathology of EAE.

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Published/Copyright: October 30, 2013

Abstract

Plasmacytoid dendritic cells (pDC) are a sub-population of dendritic cells (DC) that produce large amounts of type I interferon (IFN) in response to nucleic acids that bind and activate toll-like-receptor (TLR)9 and TLR7. Type I IFN can regulate the function of B, T, DC, and natural killer (NK) cells and can also alter the residence time of leukocytes within lymph nodes. Activated pDC can also function as antigen presenting cells (APC) and have the potential to prime and differentiate T cells into regulatory or inflammatory effector cells, depending on the context. In this review we discuss pDC ontogeny, function, trafficking, and activation. We will also examine how pDC can potentially be involved in regulating immune responses in the periphery as well as within the central nervous system (CNS) during multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE).


Corresponding author: Jennifer L. Gommerman, Department of Immunology, University of Toronto, 1 King’s College Circle, Toronto, ON M5S 1A8, Canada, e-mail:

About the authors

Georgina Galicia

Georgina Galicia completed her PhD at Catholic University of Leuven, Belgium where she studied experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Dr. Galicia then moved to Toronto to continue her studies in the Department of Immunology at the University of Toronto. Upon joining the Gommerman lab, Dr. Galicia won a post-doctroral fellowship from the MS Society of Canada. Currently Dr. Galicia investigates the immunopathology of EAE, with particular focus on cells of immune cells such as plasmacytoid dendritic cells (pDC) and B cells.

Jennifer L. Gommerman

Jen Gommerman received her PhD in 1998 from the Department of Immunology at the University of Toronto. She went on to do a post-doctoral fellowship with Dr. Michael Carroll at Harvard Medical School and subsequently joined Biogen Idec as a staff scientist under the direction of Dr. Jeffrey Browning. Dr. Gommerman returned to Toronto in 2003 to establish her laboratory in the Department of Immunology at the University of Toronto. She has received funding from the Canadian Institutes of Health Research, the MS Society of Canada and the Kidney Foundation to study the immune system in the context of health and disease. Her funding from the MS Society has allowed her to examine the role of different immune cell types in the immunopathology of EAE.

This work was funded by an operating grant from the MS Society of Canada to J.L.G and a post-doctoral fellowship from the MS Society of Canada to G.G. The authors would like to acknowledge the helpful comments from Dennis Ng.

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Received: 2013-6-27
Accepted: 2013-10-29
Published Online: 2013-10-30
Published in Print: 2014-03-01

©2014 by Walter de Gruyter Berlin Boston

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