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Structural-tridimensional study of yolk sac in pregnancies complicated by diabetes

  • Erich Cosmi , Juan J. Piazze , Angelo Ruozi , Maurizio M. Anceschi , Renato La Torre , Alessandra Andrisani , Pietro Litta , Giovanni Battista Nardelli and Guido Ambrosini
Published/Copyright: June 1, 2005
Journal of Perinatal Medicine
From the journal Volume 33 Issue 2

Abstract

Objectives: To assess by two- and three-dimensional ultrasound the diameter and volume of the yolk sac in pregnant women affected by type 1 diabetes during the first trimester of pregnancy.

Methods: 18 women affected by insulin-dependent diabetes mellitus (IDDM) and 52 normoglycemic pregnant women (controls) were enrolled in this study. The women were evaluated once a week (5–12 weeks of pregnancy). Ultrasound examination in all pregnant women was initially performed in a bidimensional fashion with a transvaginal 6.5-MHz probe and subsequently using a three-dimensional technique.

Results: In the pregnant diabetic women the diameter of the yolk sac was significantly higher than that of controls in the first weeks of pregnancy, reaching a maximum diameter at 9 weeks, and decreasing thereafter, earlier than controls. The volume of the yolk sac increased in both groups from 5 weeks of pregnancy and reached maximum values at 10 weeks in both groups. The volumetric increase and decrease after reaching highest values were greater in IDDM patients.

Conclusion: The clinical and diagnostic implications of the results of this study are still to be defined. Such a diagnostic technique may prove to be an additional element in monitoring diabetic women during early pregnancy.

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Corresponding author: Erich Cosmi, MD, Assistant Professor of Obstetrics and Gynecology, University of Padua Via Giustiniani 3 35100 Padua/Italy, Tel.: +39-339-8146745; Fax: +39-049-8213409;

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Published Online: 2005-06-01
Published in Print: 2005-03-01

©2005 by Walter de Gruyter Berlin New York

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