Unusually high alkaline phosphatase due to intestinal isoenzyme in a healthy adult
-
Sung R. Cho
, Young A. Lim and Wee G. Lee
Abstract
Intestinal alkaline phosphatase (ALP) is more prevalent in individuals of blood group O or B, and increases after a meal, especially on a high-fat diet. We did not realize that clinicians could underestimate the importance of fasting for ALP measurement until one healthy adult showed a huge difference in ALP levels before and after a meal. We report a case of transient hyperphosphatasemia resulting in unnecessary workup due to intestinal ALP in a healthy adult of blood group O.
References
1. Beckman L, Olivecrona T, Hernell O. Serum lipids and their relations to blood groups and serum alkaline phosphatase isoenzymes. Human Hered 1970; 20:569–79.10.1159/000152362Search in Google Scholar
2. Denborough MA, Prineas RJ, Downing HJ. Serum intestinal alkaline phosphatase, ABO blood group, secretor status, and lipaemia. Clin Gen 1971; 2:347–51.10.1111/j.1399-0004.1971.tb00295.xSearch in Google Scholar
3. Reynoso G, Elias EG, Mittelman A. The contribution of the intestinal mucosa to the total serum alkaline phosphatase activity. Am J Clin Pathol 1971; 56:707–12.10.1093/ajcp/56.6.707Search in Google Scholar
4. Hirano K, Matsumoto H, Tanaka T, Hayashi Y, Iino S, Domar U, et al. Specific assays for human alkaline phosphatase isozymes. Clin Chim Acta 1987; 166:265–73.10.1016/0009-8981(87)90429-3Search in Google Scholar
5. Domar U, Karpe F, Hamsten A, Stigbrand T, Olivecrona T. Human intestinal alkaline phosphatase-release to the blood is linked to lipid absorption, but removal from the blood is not linked to lipoprotein clearance. Eur J Clin Invest 1993; 23:753–60.10.1111/j.1365-2362.1993.tb01296.xSearch in Google Scholar
6. Hanna SD, Mircheff AK, Wright EM. Alkaline phosphatase of basolateral and brush border plasma membranes from intestinal epithelium. J Supramol Struct 1979; 11:451–66.10.1002/jss.400110404Search in Google Scholar
7. Deng JT, Hoylaerts MF, Van Hoof VO, De Broe ME. Differential release of human intestinal alkaline phosphatase in duodenal fluid and serum. Clin Chem 1992; 38:2532–8.10.1093/clinchem/38.12.2532Search in Google Scholar
8. Bayer PM, Hotschek H, Knoth E. Intestinal alkaline phosphatase and the ABO blood group system – a new aspect. Clin Chim Acta 1980; 108:81–7.10.1016/0009-8981(80)90295-8Search in Google Scholar
9. Griffiths WC, Camara PD, Rosner M, Lev R, Brooks EM. Prevalence and properties of the intestinal alkaline phosphatase identified in serum by cellulose acetate electrophoresis. Clin Chem 1992; 38:507–11.10.1093/clinchem/38.4.507Search in Google Scholar
10. Day AP, Feher MD, Chopra R, Mayne PD. The effect of bezafibrate treatment on serum alkaline phosphatase isoenzyme activities. Metabolism 1993; 42:839–42.10.1016/0026-0495(93)90056-TSearch in Google Scholar
11. Kleerekoper M, Horne M, Cornish CJ, Posen S. Serum alkaline phosphatase after fat ingestion: an immunological study. Clin Sci 1970; 38:339–45.10.1042/cs0380339Search in Google Scholar
12. Langman MJ, Leuthold E, Robson EB, Harris J, Luffman JE, Harris H. Influence of diet on the intestinal component of serum alkaline phosphatase in people of different ABO blood groups and secretor status. Nature 1966; 212:41–3.10.1038/212041a0Search in Google Scholar
13. Cho SR, Huh JY, Park IJ, Rheem I. Prevalence and clinical significance of intestinal alkaline phosphatase in healthy adults. Korean J Lab Med 2004; 24:87–90.Search in Google Scholar
14. McEvoy M, Skrabanek P, Wright E, Powell D, McDonagh B. Family with raised serum alkaline phosphatase activity in the absence of disease. Br Med J 1981; 282:1272.10.1136/bmj.282.6272.1272Search in Google Scholar
15. Panteghini M. Benign inherited hyperphosphatasemia of intestinal origin: report of two cases and a brief review of the literature. Clin Chem 1991; 37:1449–52.10.1093/clinchem/37.8.1449Search in Google Scholar
16. Hoshino T, Kumasaka K, Kawano K, Yamagishi F, Sakai H, Komoda T. A case of benign familial hyperphosphatasemia of intestinal origin. Clin Biochem 1993; 26:421–5.10.1016/0009-9120(93)90120-USearch in Google Scholar
©2005 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Cervical human papillomavirus screening by PCR: advantages of targeting the E6/E7 region
- Isotretinoin therapy induces DNA oxidative damage
- Structural evaluation of plasma α2-macroglobulin in acute pancreatitis
- Failure of the PAXgene™ Blood RNA System to maintain mRNA stability in whole blood
- Reticulocyte hemoglobin measurement – comparison of two methods in the diagnosis of iron-restricted erythropoiesis
- Physical analysis of ejaculate to evaluate the secretory activity of the seminal vesicles and prostate
- Specificity of the 3H-triolein assay for pancreatic lipase in blood plasma
- Effects of hemolysis and storage condition on neuron-specific enolase (NSE) in cerebrospinal fluid and serum: implications in clinical practice
- Plasma levels of 7-hydroxymetabolites of dehydroepiandrosterone in healthy Central European aging men
- Prevalence of abnormal thyroid stimulating hormone and thyroid peroxidase antibody-positive results in a population of pregnant women in the Samara region of the Russian Federation
- Impact of standardized calibration on the inter-assay variation of 14 automated assays for the measurement of creatinine in human serum
- Efficacy of three ELISA measurements of anti-cyclic citrullinated peptide antibodies in the early diagnosis of rheumatoid arthritis
- Mean and variance quality control for multiple correlated levels of replicated control samples
- Clinical evaluation of serodiagnosis of active tuberculosis by multiple-antigen ELISA using lipids from Mycobacterium bovis BCG Tokyo 172
- Analytical evaluation of the Dade Behring Dimension RxL automated N-Terminal proBNP (NT-proBNP) method and comparison with the Roche Elecsys 2010
- Unusually high alkaline phosphatase due to intestinal isoenzyme in a healthy adult
- Deficient α-galactosidase A activity in plasma but no Fabry disease – a pitfall in diagnosis
- Reportable interval of patient examination results and ISO 15189
Articles in the same Issue
- Cervical human papillomavirus screening by PCR: advantages of targeting the E6/E7 region
- Isotretinoin therapy induces DNA oxidative damage
- Structural evaluation of plasma α2-macroglobulin in acute pancreatitis
- Failure of the PAXgene™ Blood RNA System to maintain mRNA stability in whole blood
- Reticulocyte hemoglobin measurement – comparison of two methods in the diagnosis of iron-restricted erythropoiesis
- Physical analysis of ejaculate to evaluate the secretory activity of the seminal vesicles and prostate
- Specificity of the 3H-triolein assay for pancreatic lipase in blood plasma
- Effects of hemolysis and storage condition on neuron-specific enolase (NSE) in cerebrospinal fluid and serum: implications in clinical practice
- Plasma levels of 7-hydroxymetabolites of dehydroepiandrosterone in healthy Central European aging men
- Prevalence of abnormal thyroid stimulating hormone and thyroid peroxidase antibody-positive results in a population of pregnant women in the Samara region of the Russian Federation
- Impact of standardized calibration on the inter-assay variation of 14 automated assays for the measurement of creatinine in human serum
- Efficacy of three ELISA measurements of anti-cyclic citrullinated peptide antibodies in the early diagnosis of rheumatoid arthritis
- Mean and variance quality control for multiple correlated levels of replicated control samples
- Clinical evaluation of serodiagnosis of active tuberculosis by multiple-antigen ELISA using lipids from Mycobacterium bovis BCG Tokyo 172
- Analytical evaluation of the Dade Behring Dimension RxL automated N-Terminal proBNP (NT-proBNP) method and comparison with the Roche Elecsys 2010
- Unusually high alkaline phosphatase due to intestinal isoenzyme in a healthy adult
- Deficient α-galactosidase A activity in plasma but no Fabry disease – a pitfall in diagnosis
- Reportable interval of patient examination results and ISO 15189