Non-Alkaloidal Compounds from the Bulbs of the Egyptian Plant Pancratium maritimum
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Sabrin R. M. Ibrahim
Phytochemical investigation of the cytotoxic fractions of fresh bulbs of Pancratium maritimum L. led to the isolation and structure identification of two new compounds, pancricin (1) and pancrichromone (4), together with four known compounds, including 2,4-dihydroxy-6- methoxy-3-methyl acetophenone (2), 5-formylfurfuryl acetate (3), 7-β-D-glucosyloxy-5-hydroxy-2- methylchromone (5), and ethyl-b-D-glucopyranoside (6). Their structures were established on the basis of 1D and 2D NMR spectroscopy (1H, 13C, COSY, HSQC, and HMBC), as well as HR mass spectral analyses. The compounds were evaluated for their antimigratory and antiproliferative activities against the highly metastatic human prostate cancer cell line (PC-3M). Compound 5 was the most active compound displaying good activity in the proliferation assay comparable to that of the positive control 4-hydroxyphenylmethylene hydantoin, while it displayed only weak antimigratory activity compared to the positive control 4-ethylmercaptophenylmethylene hydantoin.
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Artikel in diesem Heft
- A New Ergostane Triterpenoid from a Solid Culture of the Basidiomycete Inocybe lilacina
- Non-Alkaloidal Compounds from the Bulbs of the Egyptian Plant Pancratium maritimum
- In vitro Investigation of Anticancer, Cell-Cycle-Inhibitory, and Apoptosis-Inducing Effects of Diversin, a Natural Prenylated Coumarin, on Bladder Carcinoma Cells
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- Cytotoxic Polyacetylenes from the Red Sea Sponge Siphonochalina siphonella
- The Co-Occurrence of Two Pyridine Alkaloids, Mimosine and Trigonelline, in Leucaena leucocephala
- Aqueous Garlic Extract Alleviates Liver Fibrosis and Renal Dysfunction in Bile-Duct-Ligated Rats
- The Wheat Aquaporin Gene TaAQP7 Confers Tolerance to Cold Stress in Transgenic Tobacco
- Isolation and Characterization of Wild-Type Lipoxygenase LOXPsa1 from Pleurotus sapidus
- Molecular Cloning and Characterization of a Bombyx mori Gene Encoding the Transcription Factor Atonal
- Total Antioxidant Capacity of Feces of Mammalian Herbivores and Carnivores
- Direct Asymmetric Aldol Reactions Catalyzed by Lipase from Porcine Pancreas
Artikel in diesem Heft
- A New Ergostane Triterpenoid from a Solid Culture of the Basidiomycete Inocybe lilacina
- Non-Alkaloidal Compounds from the Bulbs of the Egyptian Plant Pancratium maritimum
- In vitro Investigation of Anticancer, Cell-Cycle-Inhibitory, and Apoptosis-Inducing Effects of Diversin, a Natural Prenylated Coumarin, on Bladder Carcinoma Cells
- Antileishmanial Compounds from Moringa oleifera Lam.
- Cytotoxic Polyacetylenes from the Red Sea Sponge Siphonochalina siphonella
- The Co-Occurrence of Two Pyridine Alkaloids, Mimosine and Trigonelline, in Leucaena leucocephala
- Aqueous Garlic Extract Alleviates Liver Fibrosis and Renal Dysfunction in Bile-Duct-Ligated Rats
- The Wheat Aquaporin Gene TaAQP7 Confers Tolerance to Cold Stress in Transgenic Tobacco
- Isolation and Characterization of Wild-Type Lipoxygenase LOXPsa1 from Pleurotus sapidus
- Molecular Cloning and Characterization of a Bombyx mori Gene Encoding the Transcription Factor Atonal
- Total Antioxidant Capacity of Feces of Mammalian Herbivores and Carnivores
- Direct Asymmetric Aldol Reactions Catalyzed by Lipase from Porcine Pancreas
