Startseite Adrenal gland size in growth restricted fetuses
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Adrenal gland size in growth restricted fetuses

  • Sandra Heese EMAIL logo , Kerstin Hammer , Mareike Möllers , Helen A. Köster , Maria K. Falkenberg , Maria Eveslage , Janina Braun , Kathrin Oelmeier de Murcia , Walter Klockenbusch und Ralf Schmitz EMAIL logo
Veröffentlicht/Copyright: 15. März 2018

Abstract

Objective

To compare the adrenal gland size of fetal growth restricted (FGR) and normal control fetuses.

Study design

In this prospective study the adrenal gland size of 63 FGR fetuses and 343 normal controls was measured between 20 and 41 weeks of gestation. The total width and the medulla width were measured in a new standardized transversal plane. The cortex width and a calculated ratio of the total and medulla width (adrenal gland ratio) were compared between both groups.

Results

The mean cortex width and the adrenal gland ratio in FGR fetuses were higher in comparison to the controls (P<0.001; P=0.036, respectively). The cortex width correlated positively with the gestational age (control group: P<0.001; FGR group: P=0.089) whilst the adrenal gland ratio showed no association with the gestational age (control group: P=0.153; FGR group: P=0.314).

Conclusion

The adrenal gland cortex width and the adrenal gland ratio were increased in FGR fetuses compared to normal fetuses.


Corresponding authors: Sandra Heese and PD Dr. Ralf Schmitz, MD, Department of Obstetrics and Gynecology, University Hospital of Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany, Tel.: +49-16095211934, Fax: +49-2518348210

  1. Author’s statement

  2. Conflict of interest: Authors state no conflict of interest.

  3. Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.

  4. Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.

References

[1] Unterscheider J, Daly S, Geary MP, Kennelly MM, McAuliffe FM, O’Donoghue K, et al. Optimizing the definition of intrauterine growth restriction: the multicenter prospective PORTO Study. Am J Obstet Gynecol. 2013;208:290.e1–6.10.1097/OGX.0b013e3182a0597fSuche in Google Scholar

[2] Krause K, Mollers M, Hammer K, Falkenberg MK, Mollmann U, Gorlich D, et al. Quantification of mechanical dyssynchrony in growth restricted fetuses and normal controls using speckle tracking echocardiography (STE). J Perinat Med. 2017;45:821–7.10.1515/jpm-2016-0280Suche in Google Scholar PubMed

[3] Gordijn SJ, Beune IM, Thilaganathan B, Papageorghiou A, Baschat AA, Baker PN, et al. Consensus definition of fetal growth restriction: a Delphi procedure. Ultrasound Obstet Gynecol. 2016;48:333–9.10.1002/uog.15884Suche in Google Scholar PubMed

[4] Baschat A. Fetal growth restriction – from observation to intervention. J Perinat Med. 2010;38:239–46.10.1515/jpm.2010.041Suche in Google Scholar PubMed

[5] Gardosi J. New definition of small for gestational age based on fetal growth potential. Horm Res. 2006;65:15–8.10.1159/000091501Suche in Google Scholar PubMed

[6] Nicolaides NC, Kyratzi E, Lamprokostopoulou A, Chrousos GP, Charmandari E. Stress, the stress system and the role of glucocorticoids. Neuroimmunomodulation. 2015;22:6–19.10.1159/000362736Suche in Google Scholar PubMed

[7] Kanczkowski W, Sue M, Bornstein SR. Adrenal gland microenvironment and its involvement in the regulation of stress-induced hormone secretion during sepsis. Front Endocrinol (Lausanne). 2016;7:156.10.3389/fendo.2016.00156Suche in Google Scholar PubMed PubMed Central

[8] Beshay V, Carr B, Rainey W. The human fetal adrenal gland, corticotropin-releasing hormone, and parturition. Semin Reprod Med. 2007;25:14–20.10.1055/s-2006-956772Suche in Google Scholar PubMed

[9] Turan OM, Turan S, Funai EF, Buhimschi IA, Campbell CH, Bahtiyar OM, et al. Ultrasound measurement of fetal adrenal gland enlargement: an accurate predictor of preterm birth. Am J Obstet Gynecol. 2011;204:311.e1–10.10.1016/j.ajog.2010.11.034Suche in Google Scholar PubMed

[10] Hoffman Sage Y, Lee L, Thomas AM, Benson CB, Shipp TD. Fetal adrenal gland volume and preterm birth: a prospective third-trimester screening evaluation. J Matern Fetal Neonatal Med. 2016;29:1552–5.10.3109/14767058.2015.1059811Suche in Google Scholar PubMed

[11] Trivedi S, Joachim M, McElrath T, Kliman H, Allred E, Fichorova R, et al. Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery. Am J Obstet Gynecol. 2012;206:236.e1–8.10.1016/j.ajog.2011.12.004Suche in Google Scholar

[12] Garcia-Flores J, Cruceyra M, Canamares M, Garicano A, Espada M, Nieto O, et al. Sonographic evaluation of fetal adrenal gland in gestational diabetes: relation to fetal growth and maternal biochemical markers. J Ultrasound Med. 2017;36:999–1007.10.7863/ultra.16.03005Suche in Google Scholar

[13] Turan O, Turan S, Buhimschi I, Funai E, Campbell K, Bahtiyar O, et al. Comparative analysis of 2-D versus 3-D ultrasound estimation of the fetal adrenal gland volume and prediction of preterm birth. Am J Perinatol. 2012;29:673–80.10.1055/s-0032-1314887Suche in Google Scholar

[14] Ibrahim MI, Sherif A, El-Kady M, Ellaithy M, Husseiny A, Kamal M, et al. Can three-dimensional ultrasound measurement of fetal adrenal gland enlargement predict preterm birth? Arch Gynecol Obstet. 2015;292:569–78.10.1007/s00404-015-3668-3Suche in Google Scholar

[15] Chang C, Yu C, Chang F, Ko H, Chen H. Assessment of fetal adrenal gland volume using three-dimensional ultrasound. Ultrasound Med Biol. 2002;28:1383–7.10.1016/S0301-5629(02)00650-6Suche in Google Scholar

[16] Hata K, Hata T, Kitao M. Ultrasonographic identification and measurement of the human fetal adrenal gland in utero. Int J Gynaecol Obstet. 1985;23:355–9.10.1016/0020-7292(85)90143-2Suche in Google Scholar

[17] van Vuuren SH, Damen-Elias HA, Stigter RH, van der Doef R, Goldschmeding R, de Jong TP, et al. Size and volume charts of fetal kidney, renal pelvis and adrenal gland. Ultrasound Obstet Gynecol. 2012;40:659–64.10.1002/uog.11169Suche in Google Scholar

[18] Helfer TM, Rolo LC, Okasaki NA, de Castro Maldonado AA, Rabachini Caetano AC, Perez Zamarian AC, et al. Reference ranges of fetal adrenal gland and fetal zone volumes between 24 and 37+6 weeks of gestation by three-dimensional ultrasound. J Matern Fetal Neonatal Med. 2017;30:568–73.10.1080/14767058.2016.1178226Suche in Google Scholar

[19] Fleiss J, editor. The design and analysis of clinical experiments. New York: John Wiley and Sons; 1986.Suche in Google Scholar

[20] Mesiano S, Jaffe RB. Role of growth factors in the developmental regulation of the human fetal adrenal cortex. Steroids. 1997;62:62–72.10.1016/S0039-128X(96)00161-4Suche in Google Scholar

[21] Spencer SJ, Mesiano S, Lee JY, Jaffe RB. Proliferation and apoptosis in the human adrenal cortex during the fetal and perinatal periods: implications for growth and remodeling. J Clin Endocrinol Metab. 1999;84:1110–5.10.1210/jc.84.3.1110Suche in Google Scholar

[22] Barwick TD, Malhotra A, Webb JA, Savage MO, Reznek RH. Embryology of the adrenal glands and its relevance to diagnostic imaging. Clin Radiol. 2005;60:953–9.10.1016/j.crad.2005.04.006Suche in Google Scholar

[23] Turan OM, Turan S, Funai EF, Buhimschi IA, Copel JA, Buhimschi CS. Fetal adrenal gland volume: a novel method to identify women at risk for impending preterm birth. Obstet Gynecol. 2007;109:855–62.10.1097/01.AOG.0000258282.47919.41Suche in Google Scholar

[24] Hoffman MK, Turan OM, Parker CB, Wapner RJ, Wing DA, Haas DM, et al. Ultrasound measurement of the fetal adrenal gland as a predictor of spontaneous preterm birth. Obstet Gynecol. 2016;127:726–34.10.1097/AOG.0000000000001342Suche in Google Scholar

[25] Gielchinsky Y, Zvanca M, Akolekar R, Calvo JR, Nicolaides KH. Adrenal gland length in euploid and trisomy 18 fetuses at 11–13 weeks. Prenat Diagn. 2011;31:773–7.10.1002/pd.2765Suche in Google Scholar

[26] Chang CH, Yu CH, Chang FM, Ko HC, Chen HY. Assessment of fetal adrenal gland volume using three-dimensional ultrasound. Ultrasound Med Biol. 2002;28:1383–7.10.1016/S0301-5629(02)00650-6Suche in Google Scholar

[27] Norwitz ER, Robinson JN, Challis JR. The control of labor. N Engl J Med. 1999;341:660–6.10.1056/NEJM199908263410906Suche in Google Scholar PubMed

Received: 2017-10-28
Accepted: 2018-02-19
Published Online: 2018-03-15
Published in Print: 2018-10-25

©2018 Walter de Gruyter GmbH, Berlin/Boston

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