Startseite Association between neck circumference and non-alcoholic fatty liver disease in Mexican children and adolescents with obesity
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Association between neck circumference and non-alcoholic fatty liver disease in Mexican children and adolescents with obesity

  • Rubén Peña-Vélez ORCID logo , Nayely Garibay-Nieto ORCID logo , Manuel Cal-y-Mayor-Villalobos ORCID logo , Estibalitz Laresgoiti-Servitje ORCID logo , Karen Pedraza-Escudero ORCID logo , María del Carmen García-Blanco ORCID logo , Omar Alfonso Heredia-Nieto ORCID logo und Eréndira Villanueva-Ortega ORCID logo EMAIL logo
Veröffentlicht/Copyright: 16. Dezember 2019
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 33 Heft 2

Abstract

Background

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disorder in the pediatric population and has grown along with the obesity pandemic in which we live today. Adipose tissue storage in the upper body segment has been positively correlated with visceral adiposity and metabolic disease, which suggests that neck circumference could represent an easily accessible and replicable anthropometric measurement to identify patients with a higher risk of developing NAFLD. The main purpose of this study is to determine if there is an association between neck circumference and NAFLD. The secondary objectives are to establish cutoff values based on gender and puberty staging.

Methods

We included a sample pediatric population of 112 patients diagnosed with obesity aged between 6 and 18 years. We performed anthropometric and metabolic measurements on every patient, and NAFLD diagnosis was determined with hepatic ultrasound.

Results

The neck circumference was larger in NAFLD pediatric patients compared to those without NAFLD (p = 0.001). In a multivariate analysis, the neck circumference was associated with NAFLD as an independent risk factor (odds ratio [OR] = 1.172; 95% CI = 1.008–1.362; p = 0.038). Tanner 2–3 = 35 cm and Tanner 4–5 = 38 cm were established as risk cutoff values to develop NAFLD in the male adolescent population.

Conclusions

There is an association between the neck circumference and NAFLD in pediatric patients with obesity, particularly in the male population.

Keywords: childhood obesity; neck circumference; non-alcoholic fatty liver disease; obesity
Corresponding author: Eréndira Villanueva-Ortega, MSc, MD, Children and Adolescent Obesity Clinic, Hospital General de México “Dr. Eduardo Liceaga”, Dr. Balmis 148, Col. Doctores. Delegación, Cuauhtémoc, Mexico City, CP 06720, Mexico; and School of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico, Phone: +52 (55) 27892000, Cell Phone: +52(55) 12949092

Acknowledgments

We want to thank the patients and parents from the Children and Adolescent Obesity Clinic that took part in our study.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: None declared.

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Received: 2019-05-07
Accepted: 2019-11-05
Published Online: 2019-12-16
Published in Print: 2020-02-25

©2020 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Original Articles
  3. Air occlusion in insulin pumps of children and adolescents with type 1 diabetes
  4. Gastrointestinal symptoms in pediatric patients with type 1 diabetes mellitus
  5. Adherence to multiple medications in the TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) cohort: effect of additional medications on adherence to primary diabetes medication
  6. Ghrelin, obestatin and the ghrelin/obestatin ratio as potential mediators for food intake among obese children: a case control study
  7. Association between neck circumference and non-alcoholic fatty liver disease in Mexican children and adolescents with obesity
  8. Comparison between metabolically healthy obesity and metabolically unhealthy obesity by different definitions among Mexican children
  9. Evidence in obese children: contribution of tri-ponderal mass index or body mass index to dyslipidemia, obesity-inflammation, and insulin sensitivity
  10. Prevalence of metabolic syndrome and its associated factors in overweight and obese adolescents
  11. Cortisol secretion pattern in overweight/obese and normal-weight infants: a cross-sectional study
  12. Predictors of non-alcoholic fatty liver disease (NAFLD) among children with obesity
  13. Relative leptin deficiency in children with severe early-onset obesity (SEOO) – results of the Early-onset Obesity and Leptin – German-Polish Study (EOL-GPS)
  14. Novel associations of serum adropin and lipopolysaccharide-binding protein versus lipid profiles in childhood obesity
  15. The trade-off between the olfactory bulb and eyeball volume in precocious puberty
  16. Gender-based differences in the clustering of metabolic syndrome factors in children and adolescents
  17. Presentation of 14 alkaptonuria patients from Turkey
  18. Assessment of health-related quality of life in Egyptian children and adolescents with congenital adrenal hyperplasia
  19. Case Reports
  20. Familial hypophosphatemic rickets caused by a PHEX gene mutation accompanied by a NPR2 missense mutation
  21. Cinacalcet treatment experience in hereditary vitamin D resistant rickets
  22. Can we effectively predict the occurrence of cerebral edema in children with ketoacidosis in the course of type 1 diabetes? – case report and literature review
https://doi.org/10.1515/jpem-2019-0204
Schlagwörter für diesen Artikel
childhood obesity; neck circumference; non-alcoholic fatty liver disease; obesity

Artikel in diesem Heft

  1. Frontmatter
  2. Original Articles
  3. Air occlusion in insulin pumps of children and adolescents with type 1 diabetes
  4. Gastrointestinal symptoms in pediatric patients with type 1 diabetes mellitus
  5. Adherence to multiple medications in the TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) cohort: effect of additional medications on adherence to primary diabetes medication
  6. Ghrelin, obestatin and the ghrelin/obestatin ratio as potential mediators for food intake among obese children: a case control study
  7. Association between neck circumference and non-alcoholic fatty liver disease in Mexican children and adolescents with obesity
  8. Comparison between metabolically healthy obesity and metabolically unhealthy obesity by different definitions among Mexican children
  9. Evidence in obese children: contribution of tri-ponderal mass index or body mass index to dyslipidemia, obesity-inflammation, and insulin sensitivity
  10. Prevalence of metabolic syndrome and its associated factors in overweight and obese adolescents
  11. Cortisol secretion pattern in overweight/obese and normal-weight infants: a cross-sectional study
  12. Predictors of non-alcoholic fatty liver disease (NAFLD) among children with obesity
  13. Relative leptin deficiency in children with severe early-onset obesity (SEOO) – results of the Early-onset Obesity and Leptin – German-Polish Study (EOL-GPS)
  14. Novel associations of serum adropin and lipopolysaccharide-binding protein versus lipid profiles in childhood obesity
  15. The trade-off between the olfactory bulb and eyeball volume in precocious puberty
  16. Gender-based differences in the clustering of metabolic syndrome factors in children and adolescents
  17. Presentation of 14 alkaptonuria patients from Turkey
  18. Assessment of health-related quality of life in Egyptian children and adolescents with congenital adrenal hyperplasia
  19. Case Reports
  20. Familial hypophosphatemic rickets caused by a PHEX gene mutation accompanied by a NPR2 missense mutation
  21. Cinacalcet treatment experience in hereditary vitamin D resistant rickets
  22. Can we effectively predict the occurrence of cerebral edema in children with ketoacidosis in the course of type 1 diabetes? – case report and literature review
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