Open Medicine

MANUSCRIPTS
Open Medicine encourages the submission of both substantial full-length bodies of work and shorter manuscripts that report novel findings. There are no specific length restrictions for the overall manuscript or individual sections; however, we urge the authors to present and discuss their findings in a concise and accessible manner.

All submissions must be made via online submission system Editorial Manager. In case of problems, please contact the Editorial Office of this journal at AssistantManagingEditor@degruyter.com.

SUBMISSION OF MANUSCRIPTS
Manuscripts have to be written in MS Word. For your initial submission, we recommend you upload your entire manuscript, including tables and figures, as a single PDF file. If you are invited to submit a revised manuscript, please provide us with individual files: an editable text and publication-quality figures.

For detailed information, please see Instruction for Authors.

EDITORIAL POLICY
Unpublished material: Submission of a manuscript implies that the work described is not copyrighted, published or submitted elsewhere, except in abstract form. The corresponding author should ensure that all authors approve the manuscript before its submission.
Ethical conduct of research: The authors must describe and confirm safeguards to meet ethical standards when applicable. See Editorial Policy for details.
Conflict of interest: When authors submit a manuscript, they are responsible for recognizing and disclosing financial and/or other conflicts of interest that might bias their work and/or could inappropriately influence his/her judgment. If no specified acknowledgement is given, the Editors assume that no conflict of interest exists. Authors are encouraged to fill in the ICMJE Conflicts of Interest Form (available here) and send it in the electronic format to the Managing Editor.
Copyright: All authors retain copyright, unless – due to their local circumstances – their work is not copyrighted. The copyrights are governed by the Creative-Commons Attribution Only license (CC-BY) which is compliant with Plan-S. The corresponding author grants the journal the license to use of the article, by signing the Licence To Publish. Scanned copy of license should be sent to the journal, as soon as possible.
Authorship: Authorship should be limited to those who have made a significant contribution to the conception, design, execution, or interpretation of the reported study. All those who have made significant contributions should be listed as co-authors. Where there are others who have participated in certain substantive aspects of the research project, they should be named in an Acknowledgement section. The corresponding author should ensure that all appropriate co-authors (according to the above definition) and no inappropriate co-authors are included in the author list of the manuscript, and that all co-authors have seen and approved the final version of the paper and have agreed to its submission for publication. For more details the role of authors please see: https://www.degruyter.com/publishing/for-authors/for-journal-authors/role-of-authors
Peer Review process: Our standard policy requires each paper reporting primary research or secondary analysis of primary research, together with relevant supplementary materials, to be reviewed by at least two Referees and the peer-review process is single-blind. The Editors reserve the right to decline the submitted manuscript without review, if the studies reported are not sufficiently novel or important to merit publication in the journal. Manuscripts deemed unsuitable (insufficient originality or of limited interest to the target audience) are returned to the author(s) without review. The Editor seeks advice from experts in the appropriate field. Research articles and communications are refereed by a minimum of two reviewers, review papers by at least three. Authors are requested to suggest persons competent to review their manuscript. However, please note that this will be treated only as a suggestion, and the final selection of reviewers is exclusively the Editor's decision. The final decision of acceptance in made by Managing Editor or, in case of conflict, by the Editor-in-Chief.
Scientific Misconduct: This journal publishes only original manuscripts that are not also published or going to be published elsewhere. Multiple submissions/publications, or redundant publications (re-packaging in different words of data already published by the same authors) will be rejected. If they are detected only after publication, the journal reserves the right to publish a Retraction Note. In each particular case Editors will follow COPE’s Core Practices and implement the advices.

Editor in Chief
Prof. Vittorio Calabrese, University of Catania

Managing Editor:
Magdalena Wierzchowiecka, De Gruyter

Associate – Editor:
Dr. Demetrios A. Arvanitis, Academy of Athens, Greece

Co – Editor:
Dr. Jabůrek Martin, Academy of Sciences of the Czech Republic, Prague, Czech Republic

Guest Editors:
Chi-Chang Chang, Chung-Shan Medical University, Taiwan
Ioannis Kosmas, University of Ioannina, Greece
Tetsuya Sakurai, University of Tsukuba, Japan
Zhongjie Shi, Wayne State University, USA
Ira Skvortsova, University of Innsbruck, Austria
Kehan Ren, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Simona Zaami, "Sapienza" University of Rome, Rome, Italy
Lei Huang, University of Massachusetts Medical School, USA

Editors:
Anesthesiology and intensive care
Mohankumar Doraiswa, Mercy Hospital, Fort Smith, Arkansas, USA
Alessandro Vittori, Bambino Gesù Pediatric Hospital IRCCS, Italy
Franz J. Wiedermann, Medical University of Innsbruck, Austria

Cardiology
Demetrios A. Arvanitis, Academy of Athens, Greece
Hadi Beaini, UT Southwestern Medical Center, Dallas, Texas, USA
Michael Henein, Umeå University, Sweden
Yuxin Li, Nihon University School of Medicine, Japan
Fei Luo, Second Xiangya Hospital of Central South University
Yau Sui Yu, Open University of Hong Kong, Hong Kong
Andrea Salzano, University of Leicester, England; Federico II University, Italy

Clinical microbiology and infections diseases
Roberto Di Marco, University of Molise, Italy
Giulio Petronio Petronio, Università degli Studi del Molise, Italy
Alessandra Piccirilli, University of L'Aquila, Italy
Caterina Sagnelli, University of Campania, Italy
Manuela Tamburro, University of Molise, Italy

Dental medicine
Lorenzo Lo Muzio, University of Foggia, Italy
Gaetano Isola, University of Catania, Italy

Diabetology
Georgios Panoutsopoulos, Health Sciences University of Peloponnese Tripoli, Greece

Endocrinology
Gian Luigi Canu, University of Cagliari, Italy

Forensic medicine
Piergiorgio Fedeli, School of Law – UNICAM, Italy
Valentina Opancina, University of Kragujevac; University Clinical Center Kragujevac, Serbia

Gastroenterology
Zsolt Barta, Kenézy University Hospital, University of Debrecen, Hungary
Gopal Krishna Dhali, School of Digestive & Liver Disease; Institute of Post Graduate Medical Education & Research, India
Yang Liu, Second Affiliated Hospital, Xi'an Jiaotong University, China
Manlio Vinciguerra, International Clinical Research Center, Czech Republic

Gynecology and Obstetrics
Jingfei Chen, The Second Xiangya Hospital, Central South University
Tullio Golia D'auge, S. Pietro Fatebenefratelli Hospital, Roma, Italy
Andrea Etrusco, University of Palermo, Italy
Tomas Fait, Charles University in Prague, Czech Republic
Simone Garzon, University of Verona, Italy
Giuseppe Gullo, University of Palermo, Italy
Jinhui Liu, The First Affiliated Hospital of Nanjing Medical University, China
Maria Matteo, University of Foggia, Foggia, Italy
Gaetano Riemma, University of Campania "Luigi Vanvitelli", Italy
Paweł Sadłecki, Provincial Hospital in Toruń, Poland
Antonio Simone Laganà, University of Palermo, Italy
Felice Sorrentino, University of Foggia, Italy

Immunology
Umair W. Khan, Senior Scientist, Invenra Inc., Madison, WI, USA

Immunology and allergology
Nobuyasu Baba, Kawasaki Medical School, Japan, Japan
Silvia Deaglio, University of Turin, Italy
Douglas M Noonan, University of Insubria, Italy
Voja Pavlovic, Institute of Physiology Medical Faculty in Nis, Serbia
Giuseppina Ruggiero, Università di Napoli "Federico II", Napoli, Italy
Gong Ying, Nanfang Hospital, Guangzhou, China
Qianxia Zhang, Harvard Medical School Boston Children’s Hospital, USA

Immunology
Umair W. Khan, Senior Scientist, Invenra Inc., Madison, WI, USA

Internal medicine
Emrah Caylak, Karatekin University in Cankiri, Turkey
Sebastiano Cicco, University of Bari, Italy
Vladimir Jurisic, University of Kragujevac, Serbia
Bertha Furlan Polegato, São Paulo State University, Brasil
Oluwafemi G. Oluwole, University of Cape Town, South Africa, University of Oxford, UK
Caterina Sagnelli, University of Campania, Italy
Andrea Salzano, University of Leicester, England; Federico II University, Italy
Braghadheeswar Thyagarajan, Kadlec Regional Medical Center, WA, USA
Manlio Vinciguerra, International Clinical Research Center, Czech Republic

Otolaryngology
Salvatore Cocuzza, University of Catania, Italy
Lorenzo Lo Muzio, University of Foggia, Italy
Yohanna Takwoingi, Department of Otolaryngology in Birmingham, UK

Medical genetics
Xiao-Long Cui, University of Chicago, USA
Damjan Glavac, University of Ljubljana, Slovenia
Michela Grosso, University of Naples Federico II, Naples, Italy
Giulia Frisso, Università degli Studi di Napoli Federico II, Naples, Italy
Haobo Li, University of Bordeaux, France
Marta Olszewska, Polish Academy of Sciences, Poland
Oluwafemi G. Oluwole, University of Cape Town, South Africa, University of Oxford, UK
Songbo Wei, University of California, USA

Molecular and experimental medicine
Demetrios A. Arvanitis, Academy of Athens, Greece
Emrah Caylak, Karatekin University in Cankiri, Turkey
Sergio Davinelli, University of Molise, Italy
Daniela Galli, University of Parma, Italy
Damjan Glavac, Uniersyty of Ljubljana, Slovenia
Lei Huang, University of Massachusetts Medical School, USA
Martin Jaburek, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Karolina Jabłońska, Histology and Embriology Department, Wroclaw Medical University, Poland
Umair W. Khan, Senior Scientist, Invenra Inc., Madison, WI, USA
Yingxiang Li, University Of Michigan Biological Sciences Building, USA
Honghe Liu, Johns Hopkins University, USA
Sanxiong Liu, New York University School of Medicine, USA
Yinzhong Lu, Shanghai Jiao Tong University School of Medicine (SJTU-SM), China
Giulia Malaguarnera, University of Catania, Italy
Miloš Milosavljević, University of Kragujevac, Serbia
Marta Olszewska, Polish Academy of Sciences, Poland
Verima Pereira, University of California, USA
Jan Pilch, Saarland University Medical Center, Germany
Xingping Qin, John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, USA
Alessandra Piccirilli, University of L'Aquila, Italy
Kehan Ren, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Manlio Vinciguerra, International Clinical Research Center, Czech Republic
Rong Wang, AtilaBioSystems, Inc, USA
Lunda Shen, Arcus Biosciences, Hayward, California, USA
Bo Li, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China
Hao Zhang, Chongqing Medical University, China

Nephrology
Mohankumar Doraiswa, Mercy Hospital, Fort Smith, Arkansas, USA
Ligia Petrica, Victor Babes University of Medicine and Pharmacy Timisoara, County Emergency Hospital, Department of Nephrology, Timisoara, Romania

Neurology
Demetrios A. Arvanitis, Academy of Athens, Greece
Hrvoje Budincevic, Sveti Duh University Hospital, Croatia
Yimin Chen, Foshan Sanshui District People’s Hospital in China, China
Panteleimon Giannakopoulos, University of Geneva School of Medicine, Switzerland
Mehmet Güney, Health Sciences University, Turkey
Tibor Hortobágyi, University of Szeged, Hungary; IOPPN, King's College London, UK
Yong Hu, New York University, USA
Lei Huang, University of Massachusetts Medical School, USA
Sang Hun Jang, Korea National University of Transportation, South Korea
Lee Jung-Ho, Kyungdong University, South Korea
Magdalena Kurnik-Łucka, Jagiellonian University Medical College, Poland
Ling Li, University of North Dakota, USA
Xuxing Liao, First People's Hospital of Foshan; Foshan Sanshui District People’s Hospital in China, China
Honghe Liu, Johns Hopkins University, USA
Yinzhong Lu, Shanghai Jiao Tong University School of Medicine (SJTU-SM), China
Sergio Modafferi, University of Catania, Italy
Xingping Qin, John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, USA
Shuiquan Yang, Foshan Sanshui District People’s Hospital, China

Neurosurgery
Benjamin Völlger, University Marburg, Germany

Oncology
Elena S. Gershtein, Russian N.N.Blokhin Cancer Research Center RAMS in Moscow, Russia
Giuseppe Gullo, University of Palermo, Italy
Zoltán Herold, Semmelweis University, Hungary
Lei Huang, University of Massachusetts Medical School, USA
Vladimir Jurisic, University of Kragujevac, Serbia
Umair W. Khan, Senior Scientist, Invenra Inc., Madison, WI, USA
Mirosław Kiedrowski, Central Clinical Hospital of the MSWiA in Warsaw, Poland
Ling Li, University of North Dakota, USA
Qian Liu, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Miloš Milosavljević, University of Kragujevac, Serbia
Pier Andrea Nicolosi, University of Milano-Bicocca , Italy
Ashish Noronha, University Of California, USA
Verima Pereira, University of California, USA
Kehan Ren, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Ira Skvortsova, University of Innsbruck, Austria
Xiaojun Sun, St. Jude Children's Research Hospital, USA
Haineng Xu, University of Pennsylvania Perelman School of Medicine, USA
Shixin Ye, University Paris-Saclay, France
Gong Ying, Nanfang Hospital, Guangzhou, China
Hao Zhang, Chongqing Medical University, China

Ophthalmology
Niccolò Castellino, University of Catania, Italy
Giulia Malaguarnera, University of Catania, Italy

Orthopedics
Clemens Baier, Hospital Mallersdorf, University Hospital of Regensburg, Asklepios Klinik Lindenlohe, Germany
Daping Cui, Shenzhen Bao'an District Central Hospital: Shenzhen, Guangdong, China
Tianlong Huang, The Second Xiangya Hospital of Central South University, China
Bo Li, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China
Przemyslaw Paradowski, Umeå University, Lund University, Sweden; Nicolaus Copernicus University in Toruń, Poland
Nikola Prodanovic, University of Kragujevac, Serbia
Pietro Ruggieri, University of Padova, Italy

Pediatrics and neonatology
Ravi Bhavsar, University of Kentucky Children’s Hospital, USA
Ianna Blanchard, University of Kentucky, USA
Marco Torella, University of Campania Luigi Vanvitelli, Italy
Kazumichi Fujioka, Kobe University Graduate School of Medicine, Japan
Stefano Nobile, Policlinico Universitario Agostino Gemelli, Italy
Alessandro Vittori, Bambino Gesù Pediatric Hospital IRCCS, Italy

Pharmacology and toxicology
Tomasz Baczek, Department of Biopharmaceutics and Pharmacodynamics Medical University of Gdansk, Poland
Damianka Getova, Medical University in Plovdiv, Bulgaria
Wenzhuo Ma, University of Rhode Island College of Pharmacy, Kingston, USA
Naomi Osakabe, Shibaura Institute of Technology, Japan
Ye Guan, AstraZeneca, USA
Umair W. Khan, Senior Scientist, Invenra Inc., Madison, WI, USA
Giulia Malaguarnera, University of Catania, Italy

Psychiatry and neuropsychiatry
Nestor Kapusta, Department of Psychoanalysis and Psychotherapy, Medical University of Vienna, Austria
Marco Carotenuto, University of Campania Luigi Vanvitelli, Naples, Italy
Alena Sidenkova, Ural State Medical University; Sverdlovsk Regional Clinical Psychiatric Hospital, Russia

Public health, epidemiology and biostatistics
Amâncio António de Sousa Carvalho, Department of the School of Health of the University of Trás-os-Montes e Alto Douro, Portugal; Research Centre on Child Studies, University of Minho, Braga, Portugal
Pietro Cipresso, IRCCS Istituto Auxologico Italiano, Italy
Haruhisa Fukuda, Kyushu University Graduate School of Medical Sciences, Japan
Enbo Ma, Faculty of Medicine, University of Tsukuba, Japan
Giancarlo Ripabelli, University of Molise, Italy
Manuela Tamburro, University of Molise, Campobasso, Italy

Pulmonology
Haobo Li, University of Bordeaux, France
Stefano Nobile, Policlinico Universitario Agostino Gemelli, Italy

Rheumatology
Oreste Gualillo, SERGAS, Santiago University Clinical Hospital and IDIS, Spain

Surgery and transplantology
Armando Calogero, University of Naples Federico II, Italy
Gian Luigi Canu, University of Cagliari, Italy
Gianluca Costa, Campus Bio-Medico University Hospital, Rome, Italy
Piero Covarelli, University of perugia, Italy
Domenico Galetta, European Institute of Oncology, Italy
Yang Liu, Second Affiliated Hospital, Xi'an Jiaotong University, China
Nicola Tartaglia, University of Foggia, Italy
Francesco Petrella, University of Milan, Italy
Tomas Poškus, Vilnius University Hospital "Santaros Klinikos", Lithuania
Roberto Cirocchi, University of Perugia, Italy
Gennaro Martines, Bari University Hospital, Italy
Aldo Rocca, University of Molise, Italy
Fausto Rosa, Fondazione Policlinico Universitario A. Gemelli IRCCS of Rome, Italy

Thoracic and cardiovascular surgery
Bruno Amato, University of Naples Federico II, Naples, Italy
Antonio Salsano, University of Genoa, Italy
Massimo Conese, University of Foggia, Foggia, Italy
Ali Dakroub, St. Francis Hospital and Heart Center, NY, USA
Wenzhuo Ma, University of Rhode Island College of Pharmacy, Kingston, USA
Kehan Ren, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Kanhua Yin, Massachusetts General Hospital, Harvard Medical School, USA

Urology
Vaclav Bunc, Faculty of P.E. and Sports Charles University, Czech Republic
Giovanni Cochetti, University of Perugia, Italy
Alessio Paladini, University of Perugia, Italy
Wolfgang J Weninger, Medical University of Vienna, Austria

Diagnostic and Interventional Radiology
Valentina Opancina, University of Kragujevac; University Clinical Center Kragujevac, Serbia

Biochemistry and Biotechnology
Giulia Malaguarnera, University of Catania, Italy

Editorial Advisory Board:
Peter J. Barnes, Imperial College School of Medicine, UK
Giuseppe Biondi-Zoccai, Sapienza University of Rome, Italy
Edward Calabrese, University of Massachusetts, Amherst, USA
Morley D. Hollenberg, University of Calgary, Canada
Amedeo Lonardo, University of Modena, Italy
Kamyar Kalantar-Zadeh, University of California, USA
Charles Nemeroff, University of Texas Austin, USA
Jonas Ranstam, Lund University, Sweden
Giuseppe Tonini, University Campus Bio-Medico, Italy
Witold Zatoński, Calisia University, Kalisz, Poland

Editorial Assistants:
Małgorzata Szostakowska-Rodzoś, Maria Skłodowska-Curie National Institute of Oncology, Poland
Srividya Velagapudi, University of Zurich, Switzerland

Publisher
DE GRUYTER Poland
Nowogrodzka St. 4/3
00-513 Warsaw, Poland
T: +48 22 245 33 55

Editorial Contact
Kumaran Rengaswamy
Assistant Managing Editor, Compuscript
AssistantManagingEditor@degruyter.com

Managing Editor
Dr. Magdalena Wierzchowiecka
Magdalena.Wierzchowiecka@degruyterbrill.com

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