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TRPM3 in the eye and in the nervous system – from new findings to novel mechanisms

  • Marc Behrendt ORCID logo
Published/Copyright: March 2, 2022
Biological Chemistry
From the journal Biological Chemistry Volume 403 Issue 8-9

Abstract

The calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid pregnenolone sulfate. TRPM3’s best understood function is its role as a peripheral noxious heat sensor in mice. However, the channel is expressed in various tissues and cell types including neurons as well as glial and epithelial cells. TRPM3 expression patterns differ between species and change during development. Furthermore, a plethora of TRPM3 variants that result from alternative splicing have been identified and the majority of these isoforms are yet to be characterized. Moreover, the mechanisms underlying regulation of TRPM3 are largely unexplored. In addition, a micro-RNA gene (miR-204) is located within the TRPM3 gene. This complexity makes it difficult to obtain a clear picture of TRPM3 characteristics. However, a clear picture is needed to unravel TRPM3’s full potential as experimental tool, diagnostic marker and therapeutic target. Therefore, the newest data related to TRPM3 have to be discussed and to be put in context as soon as possible to be up-to-date and to accelerate the translation from bench to bedside. The aim of this review is to highlight recent results and developments with particular focus on findings from studies involving ocular tissues and cells or peripheral neurons of rodents and humans.

Keywords: G protein-coupled receptor (GPCR) intracellular signaling and heat nociception; inflammatory mediators and pain; membrane protein trafficking; mouse and human dorsal root ganglion (DRG) neuron; transient receptor potential (TRP) channel melastatin 3 (TRPM3); translational medicine
Corresponding author: Marc Behrendt, Department of Experimental Pain Research, Medical Faculty Mannheim, University of Heidelberg, Ludolf-Krehl-Str. 13-17, D-68167 Mannheim, Germany, E-mail:

Acknowledgments

The author would like to thank Kyra Sohns for critically reading the manuscript.

  1. Author contributions: The author has accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The author declares no conflicts of interest regarding this article.

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Received: 2021-11-01
Accepted: 2022-02-10
Published Online: 2022-03-02
Published in Print: 2022-07-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Highlight: GBM Young Investigators (Part 4)
  3. Highlight: Young research groups in Germany – 4th edition
  4. Application of RtcB ligase to monitor self-cleaving ribozyme activity by RNA-seq
  5. On the reproducibility of enzyme reactions and kinetic modelling
  6. Structures and nucleic acid-binding preferences of the eukaryotic ARID domain
  7. Transfer RNA processing – from a structural and disease perspective
  8. Eukaryotic tRNA splicing – one goal, two strategies, many players
  9. Starting the engine of the powerhouse: mitochondrial transcription and beyond
  10. Yme2, a putative RNA recognition motif and AAA+ domain containing protein, genetically interacts with the mitochondrial protein export machinery
  11. Exceptionally versatile take II: post-translational modifications of lysine and their impact on bacterial physiology
  12. TRPM3 in the eye and in the nervous system – from new findings to novel mechanisms
  13. Identification of cytokeratin24 as a tumor suppressor for the management of head and neck cancer
https://doi.org/10.1515/hsz-2021-0403
Keywords for this article
G protein-coupled receptor (GPCR) intracellular signaling and heat nociception; inflammatory mediators and pain; membrane protein trafficking; mouse and human dorsal root ganglion (DRG) neuron; transient receptor potential (TRP) channel melastatin 3 (TRPM3); translational medicine

Articles in the same Issue

  1. Frontmatter
  2. Highlight: GBM Young Investigators (Part 4)
  3. Highlight: Young research groups in Germany – 4th edition
  4. Application of RtcB ligase to monitor self-cleaving ribozyme activity by RNA-seq
  5. On the reproducibility of enzyme reactions and kinetic modelling
  6. Structures and nucleic acid-binding preferences of the eukaryotic ARID domain
  7. Transfer RNA processing – from a structural and disease perspective
  8. Eukaryotic tRNA splicing – one goal, two strategies, many players
  9. Starting the engine of the powerhouse: mitochondrial transcription and beyond
  10. Yme2, a putative RNA recognition motif and AAA+ domain containing protein, genetically interacts with the mitochondrial protein export machinery
  11. Exceptionally versatile take II: post-translational modifications of lysine and their impact on bacterial physiology
  12. TRPM3 in the eye and in the nervous system – from new findings to novel mechanisms
  13. Identification of cytokeratin24 as a tumor suppressor for the management of head and neck cancer
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